KH-CB20

Name: KH-CB20
Brand: TargetMol
SKU: T38757
Rating: 4.5 (1 reviews)

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Catalog No. T38757Cas No. 1354448-60-4

Alias KH-CB20

KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 also inhibits DYRK1A (IC50 = 57.8 nM) and CLK3 (IC50 = 488 nM).

KH-CB20

🥰Excellent

Catalog No. T38757Alias KH-CB20Cas No. 1354448-60-4

KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 also inhibits DYRK1A (IC50 = 57.8 nM) and CLK3 (IC50 = 488 nM).

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Product Introduction

Bioactivity

Description	KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 also inhibits DYRK1A (IC50 = 57.8 nM) and CLK3 (IC50 = 488 nM).
Targets&IC50	CLK1:16.5 nM (IC50), DYRK1A:57.8 nM (IC50), CLK3:488 nM (IC50)
In vitro	KH-CB20 shows selectivity for CLK1 (IC 50 =16.5 nM) over DYRK1A (IC 50 =57.8 nM) and CLK3 (IC 50 =488 nM)[1].
Synonyms	KH-CB20

Chemical Properties

Molecular Weight	338.19
Formula	C₁₅H₁₃Cl₂N₃O₂
Cas No.	1354448-60-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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