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Bofutrelvir

🥰Excellent
Catalog No. T37173Cas No. 2103278-86-8
Alias MPro Inhibitor 11a, FB2001, DC-402234

Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.

Bofutrelvir

Bofutrelvir

🥰Excellent
Purity: 99.92%
Catalog No. T37173Alias MPro Inhibitor 11a, FB2001, DC-402234Cas No. 2103278-86-8
Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$198In StockIn Stock
5 mg$572In StockIn Stock
10 mg$813In StockIn Stock
25 mg$1,190In StockIn Stock
50 mg$1,630In StockIn Stock
100 mg$2,180In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.92%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.
Targets&IC50
Mpro:53 nM
In vitro
MPro Inhibitor 11a (24 hours) exhibits in vitro inhibitory activity against SARS-CoV-2 and its variants when combined with remdesivir treatment[1].
In vivo
In K18-hACE2 mice infected with the SARS-CoV-2 Delta variant, MPro Inhibitor 11a (100 and 200 mg/kg; intraperitoneal injection; administered once daily at 100 and 200 mg/kg on day 0 and twice daily on days 1, 2, and 3 for 4 consecutive days) demonstrated a dose-dependent efficacy against lung viral titers, effectively reducing lung viral loads[2].
SynonymsMPro Inhibitor 11a, FB2001, DC-402234
Chemical Properties
Molecular Weight452.55
FormulaC25H32N4O4
Cas No.2103278-86-8
SmilesC(N[C@@H](CC1CCCCC1)C(N[C@@H](C[C@H]2C(=O)NCC2)C=O)=O)(=O)C3=CC=4C(N3)=CC=CC4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 30 mg/mL (66.29 mM), Sonication is recommended.
DMF: 30 mg/mL (66.29 mM), Sonication is recommended.
DMSO: 80 mg/mL (176.78 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.29 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMF/DMSO
1mg5mg10mg50mg
1 mM2.2097 mL11.0485 mL22.0970 mL110.4850 mL
5 mM0.4419 mL2.2097 mL4.4194 mL22.0970 mL
10 mM0.2210 mL1.1049 mL2.2097 mL11.0485 mL
20 mM0.1105 mL0.5524 mL1.1049 mL5.5243 mL
50 mM0.0442 mL0.2210 mL0.4419 mL2.2097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SARS-CoV-2 3CLSARSCoV
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