Shopping Cart

Your shopping cart is currently empty

Bofutrelvir

Name: Bofutrelvir
Brand: TargetMol
SKU: T37173
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T37173Cas No. 2103278-86-8

Alias MPro Inhibitor 11a, FB2001, DC-402234

Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.

Bofutrelvir

🥰Excellent

Purity: 99.92%

Catalog No. T37173Alias MPro Inhibitor 11a, FB2001, DC-402234Cas No. 2103278-86-8

Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$198	In Stock	In Stock
5 mg	$572	In Stock	In Stock
10 mg	$813	In Stock	In Stock
25 mg	$1,190	In Stock	In Stock
50 mg	$1,630	In Stock	In Stock
100 mg	$2,180	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.92%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.
Targets&IC50	Mpro:53 nM
In vitro	MPro Inhibitor 11a (24 hours) exhibits in vitro inhibitory activity against SARS-CoV-2 and its variants when combined with remdesivir treatment[1].
In vivo	In K18-hACE2 mice infected with the SARS-CoV-2 Delta variant, MPro Inhibitor 11a (100 and 200 mg/kg; intraperitoneal injection; administered once daily at 100 and 200 mg/kg on day 0 and twice daily on days 1, 2, and 3 for 4 consecutive days) demonstrated a dose-dependent efficacy against lung viral titers, effectively reducing lung viral loads[2].
Synonyms	MPro Inhibitor 11a, FB2001, DC-402234

Chemical Properties

Molecular Weight	452.55
Formula	C₂₅H₃₂N₄O₄
Cas No.	2103278-86-8
Smiles	C(N[C@@H](CC1CCCCC1)C(N[C@@H](C[C@H]2C(=O)NCC2)C=O)=O)(=O)C3=CC=4C(N3)=CC=CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30 mg/mL (66.29 mM), Sonication is recommended.

DMF: 30 mg/mL (66.29 mM), Sonication is recommended.

DMSO: 145 mg/mL (320.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2097 mL	11.0485 mL	22.0970 mL	110.4850 mL
5 mM	0.4419 mL	2.2097 mL	4.4194 mL	22.0970 mL
10 mM	0.2210 mL	1.1049 mL	2.2097 mL	11.0485 mL
20 mM	0.1105 mL	0.5524 mL	1.1049 mL	5.5243 mL
50 mM	0.0442 mL	0.2210 mL	0.4419 mL	2.2097 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc