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Bofutrelvir

Name: Bofutrelvir
Brand: TargetMol
SKU: T37173
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T37173Cas No. 2103278-86-8

Alias MPro Inhibitor 11a, FB2001, DC-402234

Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.

Bofutrelvir

🥰Excellent

Purity: 99.92%

Catalog No. T37173Alias MPro Inhibitor 11a, FB2001, DC-402234Cas No. 2103278-86-8

Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.

Pack Size	Price	Availability
1 mg	$198	In Stock
5 mg	$572	In Stock
10 mg	$813	In Stock
25 mg	$1,190	In Stock
50 mg	$1,630	In Stock
100 mg	$2,180	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.92%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.
Targets&IC50	Mpro:53 nM
In vitro	MPro Inhibitor 11a (24 hours) exhibits in vitro inhibitory activity against SARS-CoV-2 and its variants when combined with remdesivir treatment[1].
In vivo	In K18-hACE2 mice infected with the SARS-CoV-2 Delta variant, MPro Inhibitor 11a (100 and 200 mg/kg; intraperitoneal injection; administered once daily at 100 and 200 mg/kg on day 0 and twice daily on days 1, 2, and 3 for 4 consecutive days) demonstrated a dose-dependent efficacy against lung viral titers, effectively reducing lung viral loads[2].
Synonyms	MPro Inhibitor 11a, FB2001, DC-402234

Chemical Properties

Molecular Weight	452.55
Formula	C₂₅H₃₂N₄O₄
Cas No.	2103278-86-8
Smiles	C(N[C@@H](CC1CCCCC1)C(N[C@@H](C[C@H]2C(=O)NCC2)C=O)=O)(=O)C3=CC=4C(N3)=CC=CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30 mg/mL (66.29 mM), Sonication is recommended.

DMF: 30 mg/mL (66.29 mM), Sonication is recommended.

DMSO: 80 mg/mL (176.78 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2097 mL	11.0485 mL	22.0970 mL	110.4850 mL
5 mM	0.4419 mL	2.2097 mL	4.4194 mL	22.0970 mL
10 mM	0.2210 mL	1.1049 mL	2.2097 mL	11.0485 mL
20 mM	0.1105 mL	0.5524 mL	1.1049 mL	5.5243 mL
50 mM	0.0442 mL	0.2210 mL	0.4419 mL	2.2097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc