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Latrunculin B
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Catalog No. T20636Cas No. 76343-94-7
Alias NSC-339663, NSC339663, NSC 339663, LAT-B, LATB, LAT B, INS115644
Latrunculin B, an alkaloid from the Red Sea sponge, is an actin polymerization inhibitor with antifungal and antiprotozoal activity.Latrunculin B modulates the electrophysiological characteristics of the pulmonary veins and attenuates the occurrence of torsade de pointes, and may be used in the study of glaucoma in adolescents.
Latrunculin B
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Catalog No. T20636Alias NSC-339663, NSC339663, NSC 339663, LAT-B, LATB, LAT B, INS115644Cas No. 76343-94-7
Latrunculin B, an alkaloid from the Red Sea sponge, is an actin polymerization inhibitor with antifungal and antiprotozoal activity.Latrunculin B modulates the electrophysiological characteristics of the pulmonary veins and attenuates the occurrence of torsade de pointes, and may be used in the study of glaucoma in adolescents.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $679 | 35 days | 35 days |
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| Description | Latrunculin B, an alkaloid from the Red Sea sponge, is an actin polymerization inhibitor with antifungal and antiprotozoal activity.Latrunculin B modulates the electrophysiological characteristics of the pulmonary veins and attenuates the occurrence of torsade de pointes, and may be used in the study of glaucoma in adolescents. |
| Targets&IC50 | HeLa cells:1.4 μM |
| In vitro | Displaying growth inhibition of HeLa cells with an IC50 value of 1.4 μM, Latrunculin B also modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes[1]. In pulmonary vein (PV) preparations, Latrunculin B (100 nM) decreases spontaneous electrical activity by 16±4%. Moreover, it reduces the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B alters the transient outward K+ current and ultra-rapid delayed rectifier K+ current, while increasing the delayed rectifier K+ current in isolated PV cardiomyocytes. Additionally, at a concentration of 100 nM, Latrunculin B decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes, attenuating stretch-induced increased spontaneous electrical activity and trigger activity[2]. |
| Synonyms | NSC-339663, NSC339663, NSC 339663, LAT-B, LATB, LAT B, INS115644 |
| Molecular Weight | 395.51 |
| Formula | C20H29NO5S |
| Cas No. | 76343-94-7 |
| Smiles | C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]2CSC(=O)N2)OC(=O)\C=C(C)/CC\C=C/1 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Soluble |
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For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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