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Nicardipine hydrochloride

Name: Nicardipine hydrochloride
Brand: TargetMol
SKU: T1215
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1215Cas No. 54527-84-3

Alias YC-93 Hydrochloride, RS-69216, Nicardipine HCl

Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.

Nicardipine hydrochloride

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Purity: 99.89%

Catalog No. T1215Alias YC-93 Hydrochloride, RS-69216, Nicardipine HClCas No. 54527-84-3

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$41	In Stock	In Stock
1 g	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Color:White

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Product Introduction

Nicardipine hydrochloride AI Summary

Nicardipine hydrochloride exhibits antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 1000.0 nM to 3981.1 nM after 72 hours of treatment. In addition, it demonstrates inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1) with an IC50 of approximately 44668.4 nM and shows activity in preventing Tau fibril formation, impacting the ERK signaling pathway, modulating Lamin A splicing, and targeting the Menin-MLL interaction in MLL-related leukemias. Furthermore, it exhibits inhibitory effects on Bloom's syndrome helicase (BLM), G9a histone lysine methyltransferase, N370S glucocerebrosidase, MPP8 chromodomain, and Polymerase Iota, with potencies ranging from 1000.0 nM to 39810.7 nM. Nicardipine hydrochloride also acts as an activator of Cytochrome P450 3A4 and inhibits Neuropeptide S receptor activity. It significantly inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at 10 μM concentrations, with inhibition percentages of 67.41% and 56.95%, respectively. However, it does not show significant activity against SARS-CoV-2 (strain BavPat1) in Vero E6 cells. Additionally, it exhibits minimal antibacterial and antifungal activities, with inhibition percentages against various pathogens ranging from -9.15% to 9.21%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nicardipine hydrochloride (YC-93 Hydrochloride) is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.
Targets&IC50	Ca2+ channel (Cardiac):1 μM (IC50)
In vitro	Nicardipine significantly reduced systolic blood pressure in spontaneously hypertensive rats. In spontaneously hypertensive rats, Nicardipine significantly decreased the intima-media thickness and increased the lumen area at the level of cerebral arteries and small molluscum arteriosum.Nicardipine increased the number of neurons in the occipital cortex and frontal cortex in the SHR and inhibited the proliferation and hypertrophy of GFAP-positive astrocytes.Nicardipine also increased the number of neurons in the CA1 area of the hippocampus. increase in the number of neurons in the CA1 region of the hippocampus and reduced the size and number of astrocytes in gray and white matter. Nicardipine (5 mg/kg) in combination with flunarizine (80 mg/kg) and nimodipine (80 mg/kg) significantly potentiated the protective effect of ethosuximide (50 mg/kg) or valproic acid (100 mg/kg) against clonic seizures in mice. Nicardipine (40 mg/kg, 2 times/day for 8 weeks) reduced plaque area by 49.2% in rabbits (cholesterol-fed).Nicardipine (40 mg/kg) reduced aortic cholesterol accumulation in cholesterol-fed rabbits by 74.5%.Nicardipine (100 mg/kg) caused a significant transient reduction in cat Nicardipine (100 mg/kg) caused a significant transient reduction in retinal blood flow in cats. Although Nicardipine (100 mg/kg) decreased mean arterial blood pressure in cats, it significantly increased blood flow to the ONH, suggesting that Nicardipine benefits optic nerve hypoplasia tissue.
Synonyms	YC-93 Hydrochloride, RS-69216, Nicardipine HCl

Chemical Properties

Molecular Weight	515.99
Formula	C₂₆H₃₀ClN₃O₆
Cas No.	54527-84-3
Smiles	C1(=C(C(C(=C(N1)C)C(=O)OC)c1cc(ccc1)[N+](=O)[O-])C(=O)OCCN(C)Cc1ccccc1)C.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (87.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9380 mL	9.6901 mL	19.3802 mL	96.9011 mL
5 mM	0.3876 mL	1.9380 mL	3.8760 mL	19.3802 mL
10 mM	0.1938 mL	0.9690 mL	1.9380 mL	9.6901 mL
20 mM	0.0969 mL	0.4845 mL	0.9690 mL	4.8451 mL
50 mM	0.0388 mL	0.1938 mL	0.3876 mL	1.9380 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc