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N33-TEG-COOH

Catalog No. T16262Cas No. 201467-81-4
Alias N3-TEG-COOH, 14-Azido-3,6,9,12-tetraoxatetradecanoic acid

N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N33-TEG-COOH

N33-TEG-COOH

Catalog No. T16262Alias N3-TEG-COOH, 14-Azido-3,6,9,12-tetraoxatetradecanoic acidCas No. 201467-81-4
N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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Product Introduction

Bioactivity
Description
N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro
N33-TEG-COOH, as detailed in Reference PMID: 26035625 (Compound 7), is a long linker utilized in the construction of PROTACs. PROTACs are heterobifunctional compounds comprising two ligands connected by a linker unit, wherein one ligand targets an E3 ubiquitin ligase protein, and the other ligand attaches to a specific protein of interest. This configuration facilitates the close proximity of the ligase to the target protein[1].
AliasN3-TEG-COOH, 14-Azido-3,6,9,12-tetraoxatetradecanoic acid
Chemical Properties
Molecular Weight277.27
FormulaC10H19N3O6
Cas No.201467-81-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (360.66 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6066 mL18.0330 mL36.0659 mL180.3296 mL
5 mM0.7213 mL3.6066 mL7.2132 mL36.0659 mL
10 mM0.3607 mL1.8033 mL3.6066 mL18.0330 mL
20 mM0.1803 mL0.9016 mL1.8033 mL9.0165 mL
50 mM0.0721 mL0.3607 mL0.7213 mL3.6066 mL
100 mM0.0361 mL0.1803 mL0.3607 mL1.8033 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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