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N33-TEG-COOH

Name: N33-TEG-COOH
Brand: TargetMol
SKU: T16262
Rating: 4.5 (1 reviews)

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Catalog No. T16262Cas No. 201467-81-4

Alias N3-TEG-COOH, 14-Azido-3,6,9,12-tetraoxatetradecanoic acid

N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N33-TEG-COOH

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Catalog No. T16262Alias N3-TEG-COOH, 14-Azido-3,6,9,12-tetraoxatetradecanoic acidCas No. 201467-81-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	N33-TEG-COOH, as detailed in Reference PMID: 26035625 (Compound 7), is a long linker utilized in the construction of PROTACs. PROTACs are heterobifunctional compounds comprising two ligands connected by a linker unit, wherein one ligand targets an E3 ubiquitin ligase protein, and the other ligand attaches to a specific protein of interest. This configuration facilitates the close proximity of the ligase to the target protein[1].
Synonyms	N3-TEG-COOH, 14-Azido-3,6,9,12-tetraoxatetradecanoic acid

Chemical Properties

Molecular Weight	277.27
Formula	C₁₀H₁₉N₃O₆
Cas No.	201467-81-4
Relative Density.	0.750-0.850 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (360.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (11.9 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6066 mL	18.0330 mL	36.0659 mL	180.3296 mL
5 mM	0.7213 mL	3.6066 mL	7.2132 mL	36.0659 mL
10 mM	0.3607 mL	1.8033 mL	3.6066 mL	18.0330 mL
20 mM	0.1803 mL	0.9016 mL	1.8033 mL	9.0165 mL
50 mM	0.0721 mL	0.3607 mL	0.7213 mL	3.6066 mL
100 mM	0.0361 mL	0.1803 mL	0.3607 mL	1.8033 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc