N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N33-TEG-COOH, as detailed in Reference PMID: 26035625 (Compound 7), is a long linker utilized in the construction of PROTACs. PROTACs are heterobifunctional compounds comprising two ligands connected by a linker unit, wherein one ligand targets an E3 ubiquitin ligase protein, and the other ligand attaches to a specific protein of interest. This configuration facilitates the close proximity of the ligase to the target protein[1].