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N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Pack Size | Price | Availability | Quantity |
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100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | N33-TEG-COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | N33-TEG-COOH, as detailed in Reference PMID: 26035625 (Compound 7), is a long linker utilized in the construction of PROTACs. PROTACs are heterobifunctional compounds comprising two ligands connected by a linker unit, wherein one ligand targets an E3 ubiquitin ligase protein, and the other ligand attaches to a specific protein of interest. This configuration facilitates the close proximity of the ligase to the target protein[1]. |
Alias | N3-TEG-COOH, 14-Azido-3,6,9,12-tetraoxatetradecanoic acid |
Molecular Weight | 277.27 |
Formula | C10H19N3O6 |
Cas No. | 201467-81-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (360.66 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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