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Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody
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Catalog No. TMAB-10770
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155). Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-10770
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155). Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155). Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Chicken,Cow,Horse,Rabbit) |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded (Mouse colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Phospho-HDAC4 (Ser246)+HDAC5 (Ser259)+HDAC7 (Ser155)) Polyclonal Antibody, Unconjugated (TMAB-10770) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded (Human colon cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Phospho-HDAC4 (Ser246)+HDAC5 (Ser259)+HDAC7 (Ser155)) Polyclonal Antibody, Unconjugated (TMAB-10770) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 3. Sample: Hela (Human) Cell Lysate at 30 μg 293T (Human) Cell Lysate at 30 μg Primary: Anti-Phospho-HDAC4 (Ser246)+HDAC5 (Ser259)+HDAC7 (Ser155) (TMAB-10770) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 119 kD Observed band size: 119 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. |
| Tissue Specificity | Ubiquitous. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human HDAC4 around the phosphorylation site of Ser246 |
| Antigen Species | Human |
| Gene Name | HDAC4 |
| Gene ID | |
| Protein Name | Histone deacetylase 4 |
| Uniprot ID | |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. |
| Molecular Weight | Theoretical: 119 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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