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Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody
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Catalog No. TMAB-10770
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155). Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody
😃Good
Catalog No. TMAB-10770
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155). Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155). Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Chicken,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. |
| Tissue Specificity | Ubiquitous. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human HDAC4 around the phosphorylation site of Ser246 |
| Antigen Species | Human |
| Gene Name | HDAC4 |
| Gene ID | |
| Protein Name | Histone deacetylase 4 |
| Uniprot ID | |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. |
| Molecular Weight | Theoretical: 119 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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