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Anti-ER alpha Antibody (7N404)
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Catalog No. TMAY-00139
Alias Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER
Anti-ER alpha Antibody (7N404) is a Rabbit antibody targeting ER alpha. Anti-ER alpha Antibody (7N404) can be used in WB.
Anti-ER alpha Antibody (7N404)
Anti-ER alpha Antibody (7N404)
😃Good
Catalog No. TMAY-00139Alias Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER
Anti-ER alpha Antibody (7N404) is a Rabbit antibody targeting ER alpha. Anti-ER alpha Antibody (7N404) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-ER alpha Antibody (7N404) is a Rabbit antibody targeting ER alpha. Anti-ER alpha Antibody (7N404) can be used in WB. |
| Alias | Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1, estrogen receptor α, estrogen receptor alpha, Estrogen Receptor, Estradiol Receptor, ESR1, ESR, ER-α, ER-Alpha, ER α, ER alpha, ER |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7N404 |
| Reactivity | Human |
| Verified Activity | Anti-ER alpha/ESR1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: MCF7 Whole Cell Lysate. -Lane B: HeLa Whole Cell Lysate. -Lane C: Molt4 Whole Cell Lysate. -Lane D: Raji Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:66 kDa. -Observed band size:79 kDa |
| Application | WB |
| Recommended Dose | WB: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human ER alpha/ESR1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent transcriptional activity. The mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Estrogen receptor alpha (ERalpha) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERalpha is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERalpha in breast cancer patients indicates invasiveness and poor prognosis. ESR1 as a direct target of miR-301a-3p and suggest that miR-301a-3p likely contributes to development of estrogen independence, which leads to a more invasive phenotype of breast cancer. Polymorphisms of the estrogen receptor gene alpha (ESR1) are consistently been associated with bone mineral density (BMD) and fracture. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to the center region of the Human ER alpha/ESR1 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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