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LC3-mHTT-IN-AN1

🥰Excellent
Catalog No. T8081Cas No. 486443-73-6

LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

LC3-mHTT-IN-AN1

LC3-mHTT-IN-AN1

🥰Excellent
Purity: 97.26%
Catalog No. T8081Cas No. 486443-73-6
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
Pack SizePriceAvailabilityQuantity
1 mg$35In Stock
5 mg$89In Stock
10 mg$147In Stock
25 mg$288In Stock
50 mg$479In Stock
100 mg$768In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Purity:97.26%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
In vitro
LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes, reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease.
Chemical Properties
Molecular Weight411.04
FormulaC15H9Br2NO3
Cas No.486443-73-6
SmilesOc1cc(\C=C2/C(=O)Nc3ccc(Br)cc23)cc(Br)c1O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (291.94 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.73 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4329 mL12.1643 mL24.3285 mL121.6427 mL
5 mM0.4866 mL2.4329 mL4.8657 mL24.3285 mL
10 mM0.2433 mL1.2164 mL2.4329 mL12.1643 mL
20 mM0.1216 mL0.6082 mL1.2164 mL6.0821 mL
50 mM0.0487 mL0.2433 mL0.4866 mL2.4329 mL
100 mM0.0243 mL0.1216 mL0.2433 mL1.2164 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Keywords

mHTT-LC3 Linker CompoundLC3-mHTT-IN-AN1LC-3-mHTT-IN-AN1LC3mHTTINAN1LC3 mHTT IN AN1InhibitorinhibitAutophagyAutophagosome-tethering compoundsATTECs
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