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Auraptene

Name: Auraptene
Brand: TargetMol
SKU: T4115
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4115Cas No. 495-02-3

Alias 7-geranyloxycoumarin

Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.

Auraptene

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Purity: 99.91%

Catalog No. T4115Alias 7-geranyloxycoumarinCas No. 495-02-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$39	In Stock	In Stock
25 mg	$59	In Stock	In Stock
50 mg	$76	In Stock	In Stock
100 mg	$139	-	In Stock
500 mg	$339	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Auraptene AI Summary

Auraptene exhibits a wide range of bioactivities across multiple targets and conditions. It has notable inhibitory activity against mouse MAO-B and MAO-A enzymes, with IC50 values of 0.0006 nM and 0.0346 nM, respectively. Additionally, it shows anticancer properties against human HT-29 cells, human PANC1 cells, and various other human cell lines, with IC50 values ranging from 58,000 nM to over 100,000 nM depending on conditions. Auraptene also demonstrates antimicrobial activity against Helicobacter pylori with an MIC of 50.0 ug/mL and antifungal activity against Aspergillus strains with MIC values ≥ 2048.0 ug/mL. In terms of enzyme inhibition, Auraptene is potent against human BACE1 (IC50 of 345100.0 nM) and 15-lipoxygenase from both soybean and human sources. The compound has mitochondrial electron transport chain inhibition effects in human T47D cells and exhibits antiviral activity against Influenza A and SARS-CoV-2 viruses, albeit at relatively high concentrations. Auraptene has also demonstrated potential anti-parkinsonian properties in a Parkinson's disease-like mouse model, showing significant inhibition of microglial and astrocyte activation and protection against dopaminergic neuronal loss. Furthermore, it induces melanogenesis in mouse Melan-a cells, increases PPARgamma agonist activity in human BMMSC cells, and displays significant antileishmanial activity against Leishmania major. Overall, Auraptene shows a broad spectrum of biological activities, ranging from antimicrobial and antiviral effects to anticancer and anti-parkinson's activities, highlighting its potential for diverse therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.
Targets&IC50	BACE1:345.1 μM.
Synonyms	7-geranyloxycoumarin

Chemical Properties

Molecular Weight	298.38
Formula	C₁₉H₂₂O₃
Cas No.	495-02-3
Smiles	CC(C)=CCCC(C)=CCOc1ccc2ccc(=O)oc2c1
Relative Density.	1.079 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (209.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3514 mL	16.7572 mL	33.5143 mL	167.5716 mL
5 mM	0.6703 mL	3.3514 mL	6.7029 mL	33.5143 mL
10 mM	0.3351 mL	1.6757 mL	3.3514 mL	16.7572 mL
20 mM	0.1676 mL	0.8379 mL	1.6757 mL	8.3786 mL
50 mM	0.0670 mL	0.3351 mL	0.6703 mL	3.3514 mL
100 mM	0.0335 mL	0.1676 mL	0.3351 mL	1.6757 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc