Shopping Cart

Remove All
Your shopping cart is currently empty

XIE18-6

Name: XIE18-6
Brand: TargetMol
SKU: T29166
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T29166Cas No. 1286862-52-9

Alias XIE186

XIE18-6 is a novel INK4C inhibitor that selectively blocks the biological activity of the p18 protein, a regulator of the cell cycle. XIE18-6 promotes the ex vivo expansion of both human and murine hematopoietic stem cells, making it a valuable tool for stem cell biology and regenerative medicine research.

XIE18-6

🥰Excellent

Purity: 99.712%

Catalog No. T29166Alias XIE186Cas No. 1286862-52-9

Pack Size	Price	Availability
5 mg	$29	In Stock
10 mg	$43	In Stock
25 mg	$87	In Stock
50 mg	$139	In Stock
100 mg	$226	In Stock
200 mg	$337	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.712%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	XIE18-6 is a novel INK4C inhibitor that selectively blocks the biological activity of the p18 protein, a regulator of the cell cycle. XIE18-6 promotes the ex vivo expansion of both human and murine hematopoietic stem cells, making it a valuable tool for stem cell biology and regenerative medicine research.
Targets&IC50	HSCs:105.5 nM (ED50)
Synonyms	XIE186

Chemical Properties

Molecular Weight	373.38
Formula	C₁₈H₁₅NO₆S
Cas No.	1286862-52-9
Smiles	CC=1C=2C(=CC(OS(=O)(=O)C3=CC=C(NC(C)=O)C=C3)=CC2)OC(=O)C1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (107.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6782 mL	13.3912 mL	26.7824 mL	133.9118 mL
5 mM	0.5356 mL	2.6782 mL	5.3565 mL	26.7824 mL
10 mM	0.2678 mL	1.3391 mL	2.6782 mL	13.3912 mL
20 mM	0.1339 mL	0.6696 mL	1.3391 mL	6.6956 mL
50 mM	0.0536 mL	0.2678 mL	0.5356 mL	2.6782 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3391 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc