Shopping Cart

Your shopping cart is currently empty

XIE18-6

Name: XIE18-6
Brand: TargetMol
SKU: T29166
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T29166Cas No. 1286862-52-9

Alias XIE186

XIE18-6 is a novel INK4C inhibitor that selectively blocks the biological activity of the p18 protein, a regulator of the cell cycle. XIE18-6 promotes the ex vivo expansion of both human and murine hematopoietic stem cells, making it a valuable tool for stem cell biology and regenerative medicine research.

XIE18-6

😃Good

Purity: 99.71%

Catalog No. T29166Alias XIE186Cas No. 1286862-52-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	-	In Stock
10 mg	$43	-	In Stock
25 mg	$87	-	In Stock
50 mg	$139	-	In Stock
100 mg	$226	-	In Stock
200 mg	$337	-	In Stock
1 mL x 10 mM (in DMSO)	$30	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.71%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	XIE18-6 is a novel INK4C inhibitor that selectively blocks the biological activity of the p18 protein, a regulator of the cell cycle. XIE18-6 promotes the ex vivo expansion of both human and murine hematopoietic stem cells, making it a valuable tool for stem cell biology and regenerative medicine research.
Targets&IC50	HSCs:105.5 nM (ED50)
Synonyms	XIE186

Chemical Properties

Molecular Weight	373.38
Formula	C₁₈H₁₅NO₆S
Cas No.	1286862-52-9
Smiles	CC=1C=2C(=CC(OS(=O)(=O)C3=CC=C(NC(C)=O)C=C3)=CC2)OC(=O)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (107.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6782 mL	13.3912 mL	26.7824 mL	133.9118 mL
5 mM	0.5356 mL	2.6782 mL	5.3565 mL	26.7824 mL
10 mM	0.2678 mL	1.3391 mL	2.6782 mL	13.3912 mL
20 mM	0.1339 mL	0.6696 mL	1.3391 mL	6.6956 mL
50 mM	0.0536 mL	0.2678 mL	0.5356 mL	2.6782 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3391 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc