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EST73502 HCl

Name: EST73502 HCl
Brand: TargetMol
SKU: T39284
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39284Cas No. 2535970-65-9

EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.

EST73502 HCl

🥰Excellent

Purity: 99.96%

Catalog No. T39284Cas No. 2535970-65-9

EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$190	In Stock
10 mg	$271	In Stock
25 mg	$447	In Stock
50 mg	$630	In Stock
100 mg	$833	In Stock
200 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$208	In Stock

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Purity:99.96%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
Targets&IC50	μ opioid receptor:64 nM(Ki), δ opioid receptor:118 nM(Ki)
In vivo	In CD1 male mice, EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test. EST73502 (5 mg/kg; i.p.) attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%[1].

Chemical Properties

Molecular Weight	388.88
Formula	C₁₉H₂₇ClF₂N₂O₂
Cas No.	2535970-65-9
Smiles	Cl.CCN1CC2(CCN(CCc3cc(F)ccc3F)CC2)O[C@H](C)C1=O
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (128.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5715 mL	12.8574 mL	25.7149 mL	128.5744 mL
5 mM	0.5143 mL	2.5715 mL	5.1430 mL	25.7149 mL
10 mM	0.2571 mL	1.2857 mL	2.5715 mL	12.8574 mL
20 mM	0.1286 mL	0.6429 mL	1.2857 mL	6.4287 mL
50 mM	0.0514 mL	0.2571 mL	0.5143 mL	2.5715 mL
100 mM	0.0257 mL	0.1286 mL	0.2571 mL	1.2857 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc