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Guanfu base G

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Catalog No. TN2338Cas No. 78969-72-9
Alias Guan-fu base G

Guanfu base G is an alkaloid isolated from Aconitum coreanum exhibiting antiarrhythmic activity by inhibiting HERG channel currents (IC50=17.9 μM).

Guanfu base G

Guanfu base G

😃Good
Purity: 99.52%
Catalog No. TN2338Alias Guan-fu base GCas No. 78969-72-9
Guanfu base G is an alkaloid isolated from Aconitum coreanum exhibiting antiarrhythmic activity by inhibiting HERG channel currents (IC50=17.9 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$123-In Stock
5 mg$289-In Stock
10 mg$428-In Stock
25 mg$698-In Stock
50 mg$968-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.52%
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Product Introduction

Bioactivity
Description
Guanfu base G is an alkaloid isolated from Aconitum coreanum exhibiting antiarrhythmic activity by inhibiting HERG channel currents (IC50=17.9 μM).
Targets&IC50
ERG channel (human):17.9 μM
In vitro
In HEK293 cells transfected with HERG complementary DNA, Guanfu base G inhibits HERG channel current in a concentration-, voltage-, and time-dependent manner and accelerates channel recovery from inactivation [2].
In vivo
Guanfu base A was detectable in rats 15 minutes after administration of Guanfu base G (5 mg/kg; intravenous injection; duration 5–1200 min). Approximately 10% of Guanfu base G was metabolized to Guanfu base A in vivo. The T1/2 of Guanfu base G in rats was 4.16 hours [1].
SynonymsGuan-fu base G
Chemical Properties
Molecular Weight471.55
FormulaC26H33NO7
Cas No.78969-72-9
SmilesO(C(C)=O)[C@H]1[C@]2([C@@]34[C@]5([C@]6(O)[C@@]2(C[C@]7([C@@]3([C@](C)(CN57)C[C@H](OC(C)=O)C4)[H])[H])CC(=C)[C@]1([C@H]6OC(C)=O)[H])[H])[H]
Relative Density.1.39 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

Guanfu base G
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