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Lysine-N,N-diacetic acid

Name: Lysine-N,N-diacetic acid
Brand: TargetMol
SKU: T77989
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77989Cas No. 113231-05-3

Alias Nα,Nα-Bis(carboxymethyl)-L-lysine, N2,N2-Bis(carboxymethyl)-L-lysine, N-(5-Amino-1-carboxypentyl)iminodiacetic acid, BCML, AB-NTA

Lysine-N,N-diacetic acid (BCML) is a highly efficient TAS2R4 inhibitor, blocking the human TAS2R4-mediated response to quinine.

Lysine-N,N-diacetic acid

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Purity: 99.76%

Catalog No. T77989Alias Nα,Nα-Bis(carboxymethyl)-L-lysine, N2,N2-Bis(carboxymethyl)-L-lysine, N-(5-Amino-1-carboxypentyl)iminodiacetic acid, BCML, AB-NTACas No. 113231-05-3

Lysine-N,N-diacetic acid (BCML) is a highly efficient TAS2R4 inhibitor, blocking the human TAS2R4-mediated response to quinine.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	-	In Stock

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lysine-N,N-diacetic acid (BCML) is a highly efficient TAS2R4 inhibitor, blocking the human TAS2R4-mediated response to quinine.
Targets&IC50	T2R4:59 nM
In vitro	Lysine-N,N-diacetic acid is a competitive inhibitor with an IC50 of 59 nM for bitter taste receptor 4 (T2R4).59 nM Lysine-N,N-diacetic acid reduces the basal activity of H214A (the constitutively active mutant of T2R4) by 40% reduction in basal activity of H214A (the constitutively active mutant of T2R4). [1] 60 nM Lysine-N,N-diacetic acid, acting for 15 minutes, prevented the quinine-induced decrease in the basal activation state of Rac1, which occurred in HEK293T cells overexpressing T2R4 and Ga16/44, but was not observed in HEK293T wild-type cells. [2]
Synonyms	Nα,Nα-Bis(carboxymethyl)-L-lysine, N2,N2-Bis(carboxymethyl)-L-lysine, N-(5-Amino-1-carboxypentyl)iminodiacetic acid, BCML, AB-NTA

Chemical Properties

Molecular Weight	262.26
Formula	C₁₀H₁₈N₂O₆
Cas No.	113231-05-3
Smiles	N([C@@H](CCCCN)C(O)=O)(CC(O)=O)CC(O)=O
Sequence	N(EtO2H2)Lys-OH
Sequence Short	K

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1 mg/mL (3.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8130 mL	19.0650 mL	38.1301 mL	190.6505 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc