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Lysine-N,N-diacetic acid
🥰Excellent
Catalog No. T77989Cas No. 113231-05-3
Alias Nα,Nα-Bis(carboxymethyl)-L-lysine, N2,N2-Bis(carboxymethyl)-L-lysine, N-(5-Amino-1-carboxypentyl)iminodiacetic acid, BCML, AB-NTA
Lysine-N,N-diacetic acid (BCML) is a highly efficient TAS2R4 inhibitor, blocking the human TAS2R4-mediated response to quinine.
Lysine-N,N-diacetic acid
🥰Excellent
Purity: 99.76%
Catalog No. T77989Alias Nα,Nα-Bis(carboxymethyl)-L-lysine, N2,N2-Bis(carboxymethyl)-L-lysine, N-(5-Amino-1-carboxypentyl)iminodiacetic acid, BCML, AB-NTACas No. 113231-05-3
Lysine-N,N-diacetic acid (BCML) is a highly efficient TAS2R4 inhibitor, blocking the human TAS2R4-mediated response to quinine.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.76%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lysine-N,N-diacetic acid (BCML) is a highly efficient TAS2R4 inhibitor, blocking the human TAS2R4-mediated response to quinine. |
| Targets&IC50 | T2R4:59 nM |
| In vitro | Lysine-N,N-diacetic acid is a competitive inhibitor with an IC50 of 59 nM for bitter taste receptor 4 (T2R4).59 nM Lysine-N,N-diacetic acid reduces the basal activity of H214A (the constitutively active mutant of T2R4) by 40% reduction in basal activity of H214A (the constitutively active mutant of T2R4). [1] 60 nM Lysine-N,N-diacetic acid, acting for 15 minutes, prevented the quinine-induced decrease in the basal activation state of Rac1, which occurred in HEK293T cells overexpressing T2R4 and Ga16/44, but was not observed in HEK293T wild-type cells. [2] |
| Synonyms | Nα,Nα-Bis(carboxymethyl)-L-lysine, N2,N2-Bis(carboxymethyl)-L-lysine, N-(5-Amino-1-carboxypentyl)iminodiacetic acid, BCML, AB-NTA |
| Molecular Weight | 262.26 |
| Formula | C10H18N2O6 |
| Cas No. | 113231-05-3 |
| Smiles | N([C@@H](CCCCN)C(O)=O)(CC(O)=O)CC(O)=O |
| Sequence | N(EtO2H2)Lys-OH |
| Sequence Short | K |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (3.81 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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