keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nα,Nα-Bis(carboxymethyl)-L-lysine is a potent competitive inhibitor of bitter taste receptor 4, exhibiting an IC50 of 59 nM. This compound finds application in studies related to bitter taste receptors [1] [2] [3].
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Description | Nα,Nα-Bis(carboxymethyl)-L-lysine is a potent competitive inhibitor of bitter taste receptor 4, exhibiting an IC50 of 59 nM. This compound finds application in studies related to bitter taste receptors [1] [2] [3]. |
In vitro | Nα,Nα-Bis(carboxymethyl)-L-lysine at a concentration of 59 nM decreased the baseline activity by 40% in H214A, a constitutively active mutant of T2R4 [1]. Furthermore, Nα,Nα-Bis(carboxymethyl)-L-lysine at 60 nM for 15 minutes inhibited the reduction of Rac1 basal activation state induced by quinine in HEK293T cells expressing T2R4 and Ga16/44, but this inhibitory effect was not observed in wild-type HEK293T cells [2]. |
In vivo | Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) does not affect the licking response to bitter substances in adult C57BL6/J mice [3]. |
Molecular Weight | 262.26 |
Formula | C10H18N2O6 |
CAS No. | 113231-05-3 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Nα,Nα-Bis(carboxymethyl)-L-lysine 113231-05-3 inhibitor inhibit