Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 430.00 | |
10 mg | In stock | $ 636.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,360.00 | |
100 mg | In stock | $ 1,830.00 | |
500 mg | In stock | $ 3,680.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 517.00 |
Description | Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor. |
Targets&IC50 | p38:< 0.005 µM, p38:1.5 µM |
In vivo | Oral treatment with the SCIO-323 included delivery for 3 weeks and stopping for 3 weeks, delivery for 3 weeks after an initial 3-week delay, and delivery for 6 weeks continuously. Administration of the SCIO-323 continuously for 6 weeks with/without the presence of particles, or for the initial 3 of 6 weeks had minor effects on bone ingrowth. After establishing a particle-induced chronic inflammatory reaction for 3 weeks, administration of SCIO-323 for a subsequent 3 weeks suppressed net bone formation. The activity of osteoclast-like cells remained low among all treatments when compared with the first control.[1] |
Molecular Weight | 479.54 |
Formula | C27H30FN3O4 |
CAS No. | 309913-51-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (57.35 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Scio-323 309913-51-7 MAPK p38 MAPK inhibitor inhibit