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Scio-323

Name: Scio-323
Brand: TargetMol
SKU: T68139
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68139Cas No. 309913-51-7

Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.

Scio-323

😃Good

Purity: 99.58%

Catalog No. T68139Cas No. 309913-51-7

Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	In Stock	In Stock
5 mg	$181	In Stock	In Stock
10 mg	$267	In Stock	In Stock
25 mg	$413	In Stock	In Stock
50 mg	$571	In Stock	In Stock
100 mg	$763	In Stock	In Stock
200 mg	$1,030	-	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:White

Resource Download

COA FNMR HNMR HPLC

Product Introduction

Bioactivity

Description	Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.
Targets&IC50	p38:< 0.005 µM, p38:1.5 µM
In vivo	Oral treatment with the SCIO-323 included delivery for 3 weeks and stopping for 3 weeks, delivery for 3 weeks after an initial 3-week delay, and delivery for 6 weeks continuously. Administration of the SCIO-323 continuously for 6 weeks with/without the presence of particles, or for the initial 3 of 6 weeks had minor effects on bone ingrowth. After establishing a particle-induced chronic inflammatory reaction for 3 weeks, administration of SCIO-323 for a subsequent 3 weeks suppressed net bone formation. The activity of osteoclast-like cells remained low among all treatments when compared with the first control.[1]

Chemical Properties

Molecular Weight	479.54
Formula	C₂₇H₃₀FN₃O₄
Cas No.	309913-51-7
Smiles	C(C(N(C)C)=O)(=O)C=1C=2C(=CC(OC)=C(C(=O)N3CCC(CC4=CC=C(F)C=C4)CC3)C2)N(C)C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (57.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0853 mL	10.4267 mL	20.8533 mL	104.2666 mL
5 mM	0.4171 mL	2.0853 mL	4.1707 mL	20.8533 mL
10 mM	0.2085 mL	1.0427 mL	2.0853 mL	10.4267 mL
20 mM	0.1043 mL	0.5213 mL	1.0427 mL	5.2133 mL
50 mM	0.0417 mL	0.2085 mL	0.4171 mL	2.0853 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc