Ligands for Target Protein for PROTAC

PROTACs consist of two covalently linked protein-binding molecules: one capable of engaging an E3 ubiquitin ligase, and another that binds to a target protein meant for degradation. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Cat. No.	Product name	CAS No.	Purity
T77921	PROTAC BRD4 ligand-2 hydrochloride		98%
T77921	PROTAC BRD4 Ligand-2 Hydrochloride serves as a ligand targeting the BRD4 protein, specifically designed for use with PROTAC CFT-2718.
T77928	PROTAC PTK6 ligand-1	2408341-98-8	98%
T77928	PROTAC PTK6 ligand-1 serves as an intermediate in the synthesis of BTK kinase inhibitors [1] and is utilized in the preparation of ARD-61 [2].
T77940	Tazemetostat de(methyl morpholine)-COOH	2685873-44-1	98%
T77940	Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degrader...
T77972	CFT1946	2882165-79-7	98%
T77972	CFT1946 is a selective and orally active ligand targeting BRAF kinase, functioning as a degrader of mutant BRAF forms including BRAFV600E, G469A, G466V, and p61-...
T77985	AZD9496 deacrylic acid phenol	2173404-70-9	98%
T77985	AZD9496 deacrylic acid phenol (AZD9496) represents a portion of the ligand that targets the protein for PROTAC ER Degrader-4 [1].
T80974	TMX-4153	2867519-91-1	98%
T80974	TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase com...
T81147	SMD-3040 TFA		98%
T81147	SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis. It demonstrates robust t...
T73909	Abemaciclib metabolite M18	2704316-81-2	98%
T73909	Abemaciclib metabolite M18 (LSN3106729) is a potent cyclin-dependent kinase (CDK) inhibitor with antitumor properties. It has been incorporated alongside a cereb...
T1835	Ibrutinib	936563-96-1	99.79%
T1835	Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T19301	DUPA	302941-52-2	99.56%
T19301	DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expr...
T12551	PROTAC BRD4 ligand-1	2313230-51-0	99.48%
T12551	PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
T2066	Quizartinib	950769-58-1	99.42%
T2066	Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T12186	Navitoclax-piperazine	2143096-93-7	99.11%
T12186	Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
T10359	AR antagonist 1	1818885-54-9	99.07%
T10359	AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PR...
T10879	CPI-0610 carboxylic acid	1380089-81-5	98.62%
T10879	CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protei...
T2110	(+)-JQ-1	1268524-70-4	98.36%
T2110	(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and...
T5480	BI-4464	1227948-02-8	97.43%
T5480	BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T13954	UNC6852	2688842-08-0	98%
T13954	UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
T18595	Dasatinib carbaldehyde	2112837-79-1	98%
T18595	Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1]....