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Ligands for Target Protein for PROTAC

PROTACs consist of two covalently linked protein-binding molecules: one capable of engaging an E3 ubiquitin ligase, and another that binds to a target protein meant for degradation. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T77921 PROTAC BRD4 ligand-2 hydrochloride 98%
PROTAC BRD4 ligand-2 hydrochloride
PROTAC BRD4 Ligand-2 Hydrochloride serves as a ligand targeting the BRD4 protein, specifically designed for use with PROTAC CFT-2718.
T77928 PROTAC PTK6 ligand-1 2408341-98-8 98%
PROTAC PTK6 ligand-1
PROTAC PTK6 ligand-1 serves as an intermediate in the synthesis of BTK kinase inhibitors [1] and is utilized in the preparation of ARD-61 [2].
T77940 Tazemetostat de(methyl morpholine)-COOH 2685873-44-1 98%
Tazemetostat de(methyl morpholine)-COOH
Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degrader...
T77972 CFT1946 2882165-79-7 98%
CFT1946
CFT1946 is a selective and orally active ligand targeting BRAF kinase, functioning as a degrader of mutant BRAF forms including BRAFV600E, G469A, G466V, and p61-...
T77985 AZD9496 deacrylic acid phenol 2173404-70-9 98%
AZD9496 deacrylic acid phenol
AZD9496 deacrylic acid phenol (AZD9496) represents a portion of the ligand that targets the protein for PROTAC ER Degrader-4 [1].
T80974 TMX-4153 2867519-91-1 98%
TMX-4153
TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase com...
T81147 SMD-3040 TFA 98%
SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis. It demonstrates robust t...
T73909 Abemaciclib metabolite M18 2704316-81-2 98%
Abemaciclib metabolite M18
Abemaciclib metabolite M18 (LSN3106729) is a potent cyclin-dependent kinase (CDK) inhibitor with antitumor properties. It has been incorporated alongside a cereb...
T1835 Ibrutinib 936563-96-1 99.79%
Ibrutinib
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T19301 DUPA 302941-52-2 99.56%
DUPA
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expr...
T12551 PROTAC BRD4 ligand-1 2313230-51-0 99.48%
PROTAC BRD4 ligand-1
PROTAC BRD4 ligand-1 is a ligand for PROTAC GNE-987 targeting the BRD4 protein and is an inhibitor of BET.
T12186 Navitoclax-piperazine 2143096-93-7 99.11%
Navitoclax-piperazine
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
T10879 CPI-0610 carboxylic acid 1380089-81-5 98.62%
CPI-0610 carboxylic acid
CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protei...
T2066 Quizartinib 950769-58-1 98.48%
Quizartinib
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T2110 (+)-JQ-1 1268524-70-4 98.00%
(+)-JQ-1
(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and...
T5480 BI-4464 1227948-02-8 97.43%
BI-4464
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T10359 AR antagonist 1 1818885-54-9
AR antagonist 1
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PR...
T13954 UNC6852 2688842-08-0 98%
UNC6852
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
T18595 Dasatinib carbaldehyde 2112837-79-1 98%
Dasatinib carbaldehyde
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1]....
PROTAC BRD4 ligand-2 hydrochloride
T77921
PROTAC BRD4 Ligand-2 Hydrochloride serves as a ligand targeting the BRD4 protein, specifically designed for use with PROTAC CFT-2718.
PROTAC PTK6 ligand-1
T77928
PROTAC PTK6 ligand-1 serves as an intermediate in the synthesis of BTK kinase inhibitors [1] and is utilized in the preparation of ARD-61 [2].
Tazemetostat de(methyl morpholine)-COOH
T77940
Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degrader...
CFT1946
T77972
CFT1946 is a selective and orally active ligand targeting BRAF kinase, functioning as a degrader of mutant BRAF forms including BRAFV600E, G469A, G466V, and p61-...
AZD9496 deacrylic acid phenol
T77985
AZD9496 deacrylic acid phenol (AZD9496) represents a portion of the ligand that targets the protein for PROTAC ER Degrader-4 [1].
TMX-4153
T80974
TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase com...
SMD-3040 TFA
T81147
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis. It demonstrates robust t...
Abemaciclib metabolite M18
T73909
Abemaciclib metabolite M18 (LSN3106729) is a potent cyclin-dependent kinase (CDK) inhibitor with antitumor properties. It has been incorporated alongside a cereb...
Ibrutinib
T1835
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
DUPA
T19301
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expr...
PROTAC BRD4 ligand-1
T12551
PROTAC BRD4 ligand-1 is a ligand for PROTAC GNE-987 targeting the BRD4 protein and is an inhibitor of BET.
Navitoclax-piperazine
T12186
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
CPI-0610 carboxylic acid
T10879
CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protei...
Quizartinib
T2066
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
(+)-JQ-1
T2110
(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and...
BI-4464
T5480
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
AR antagonist 1
T10359
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PR...
UNC6852
T13954
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
Dasatinib carbaldehyde
T18595
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1]....
TargetMol