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MTOB (Alias: α-keto-γ-Methylthiobutyric acid sodium salt, MTOB sodium salt, KMBA, 4-methylthio 2-oxobutyri...)

Name: MTOB
Brand: TargetMol
SKU: T33519
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T33519 Copy Product Info

Purity: 98.23%

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MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.

MTOB

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Catalog No. T33519

Alias α-keto-γ-Methylthiobutyric acid sodium salt, MTOB sodium salt, KMBA, 4-methylthio 2-oxobutyric acid sodium salt

Cas No. 51828-97-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$48	In Stock	In Stock
5 mg	$111	In Stock	In Stock
10 mg	$153	In Stock	In Stock
25 mg	$253	In Stock	In Stock
50 mg	$377	In Stock	-
100 mg	$558	Inquiry	Inquiry

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.23%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.
Synonyms	α-keto-γ-Methylthiobutyric acid sodium salt, MTOB sodium salt, KMBA, 4-methylthio 2-oxobutyric acid sodium salt

Chemical Properties

Molecular Weight	170.16
Formula	C₅H₇NaO₃S
Cas No.	51828-97-8
Smiles	[Na+].CSCCC(=O)C([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (323.23 mM), Sonication is recommended.

In Vivo Formulation

PBS: 100 mg/mL (587.68 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8768 mL	29.3841 mL	58.7682 mL	293.8411 mL
5 mM	1.1754 mL	5.8768 mL	11.7536 mL	58.7682 mL
10 mM	0.5877 mL	2.9384 mL	5.8768 mL	29.3841 mL
20 mM	0.2938 mL	1.4692 mL	2.9384 mL	14.6921 mL
50 mM	0.1175 mL	0.5877 mL	1.1754 mL	5.8768 mL
100 mM	0.0588 mL	0.2938 mL	0.5877 mL	2.9384 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc