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KDM5-IN-1

Name: KDM5-IN-1
Brand: TargetMol
SKU: T15649
Price: 912 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15649Cas No. 1628210-26-3

KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.

KDM5-IN-1

🥰Excellent

Purity: 99.50%

Catalog No. T15649Cas No. 1628210-26-3

KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$196	In Stock
10 mg	$298	In Stock
25 mg	$475	In Stock
50 mg	$678	In Stock
100 mg	$912	In Stock
500 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$139	In Stock

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Batch Information

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Purity:99.50%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.
Targets&IC50	PC9 H3K4Me3 cells:(EC50)0.34 μM, KDM5:15.1 nM
In vitro	KDM5-IN-1 is significantly less potent against other KDM enzymes (1A, 2B, 3B, 4C, 5A, 6A, 7B), inhibiting KDM4C the strongest with an IC50 of 1.9 μM. KDM5-IN-1 potently inhibits KDM5B and KDM5C isoforms (IC50 of 4.7 and 65.5 nM, respectively)[1].
In vivo	KDM5-IN-1(50 mg/kg; oral) shows an unbound maximal plasma concentration Cmax>15-fold over its cell EC50 in vivo[1].

Chemical Properties

Molecular Weight	324.38
Formula	C₁₇H₂₀N₆O
Cas No.	1628210-26-3
Smiles	CC(C)c1c([nH]c2c(cnn2c1=O)C#N)-c1cnn(c1)C(C)(C)C
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (92.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0828 mL	15.4140 mL	30.8280 mL	154.1402 mL
5 mM	0.6166 mL	3.0828 mL	6.1656 mL	30.8280 mL
10 mM	0.3083 mL	1.5414 mL	3.0828 mL	15.4140 mL
20 mM	0.1541 mL	0.7707 mL	1.5414 mL	7.7070 mL
50 mM	0.0617 mL	0.3083 mL	0.6166 mL	3.0828 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc