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Anti-EphB3 Antibody (1S458)

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Catalog No. TMAY-03362

Anti-EphB3 Antibody (1S458) is a Rabbit antibody targeting EphB3. Anti-EphB3 Antibody (1S458) can be used in ELISA.

Anti-EphB3 Antibody (1S458)

Anti-EphB3 Antibody (1S458)

😃Good
Catalog No. TMAY-03362
Anti-EphB3 Antibody (1S458) is a Rabbit antibody targeting EphB3. Anti-EphB3 Antibody (1S458) can be used in ELISA.
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100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-EphB3 Antibody (1S458) is a Rabbit antibody targeting EphB3. Anti-EphB3 Antibody (1S458) can be used in ELISA.
Ig Type
Monoclonal Rabbit IgG
Clone
1S458
Reactivity
Mouse
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphB3 / HEK2 (rM EphB3 / HEK2; TMPY-01784; NP_034273.1; Met 1-Thr 537).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundEphrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induces various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Mouse EphB3 / HEK2 protein (TMPY-01784)
Antigen Species
Mouse
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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