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Amphotericin B methyl ester

Name: Amphotericin B methyl ester
Brand: TargetMol
SKU: T10310
Rating: 4.5 (1 reviews)

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Amphotericin B methyl ester is a methylated derivative of the polyene antibiotic amphotericin B, belonging to cholesterol-binding compounds with potent antifungal activity. It also interferes with HIV-1 viral particle production and blocks HIV-1 replication in vivo.

Cas No. 36148-89-7

Pack Size	Price	USA Stock	Global Stock
5 mg	$209	35 days	35 days
10 mg	$378	35 days	35 days
25 mg	$879	35 days	35 days
50 mg	$1,639	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description

In vitro

Methods: In vitro experiments were conducted to explore the regulatory effect of Amphotericin B methyl ester on HIV-1 viral particle production, and its influences on the plasma membrane binding, lipid raft localization and multimerization process of Gag protein were detected.
Results: Amphotericin B methyl ester could effectively inhibit the production of HIV-1 viral particles, while it did not significantly interfere with the membrane binding, lipid raft enrichment and multimerization progression of Gag protein [1].

Chemical Properties

Molecular Weight	938.12
Formula	C₄₈H₇₅NO₁₇
Cas No.	36148-89-7
Smiles	[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)OC)O2
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (85.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0660 mL	5.3298 mL	10.6596 mL	53.2981 mL
5 mM	0.2132 mL	1.0660 mL	2.1319 mL	10.6596 mL
10 mM	0.1066 mL	0.5330 mL	1.0660 mL	5.3298 mL
20 mM	0.0533 mL	0.2665 mL	0.5330 mL	2.6649 mL
50 mM	0.0213 mL	0.1066 mL	0.2132 mL	1.0660 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Amphotericin B methyl ester

Related Tags: Amphotericin B methyl ester chemical structure | Amphotericin B methyl ester in vitro | Amphotericin B methyl ester formula | Amphotericin B methyl ester molecular weight