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Anti-Phospho-Desmin (Thr16) Polyclonal Antibody
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Catalog No. TMAB-10595
Anti-Phospho-Desmin (Thr16) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Desmin (Thr16). Anti-Phospho-Desmin (Thr16) Polyclonal Antibody can be used in WB.
Anti-Phospho-Desmin (Thr16) Polyclonal Antibody
Anti-Phospho-Desmin (Thr16) Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-10595
Anti-Phospho-Desmin (Thr16) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Desmin (Thr16). Anti-Phospho-Desmin (Thr16) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-Desmin (Thr16) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Desmin (Thr16). Anti-Phospho-Desmin (Thr16) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Cow) |
| Verified Activity | Sample: Muscle (Mouse) Lysate at 40 μg Muscle (Rat) Lysate at 20 μg Stomach (Mouse) Lysate at 40 μg Heart (Mouse) Lysate at 40 μg Primary: Anti-phospho-Desmin (Thr16) (TMAB-10595) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Desmin is a muscle-specific, type III intermediate filament that integrates the sarcolemma, Z disk, and nuclear membrane in sarcomeres and regulates sarcomere architecture. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human DES around the phosphorylation site of Thr16 |
| Antigen Species | Human |
| Gene Name | DES |
| Gene ID | |
| Protein Name | Desmin |
| Uniprot ID | |
| Function | Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. |
| Molecular Weight | Theoretical: 52 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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