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PDE12-IN-1

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Catalog No. T39796Cas No. 2259620-80-7
Alias PDE12-IN-1

PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity.

PDE12-IN-1

PDE12-IN-1

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Catalog No. T39796Alias PDE12-IN-1Cas No. 2259620-80-7
PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$996InquiryInquiry
10 mg$1,690InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity.
Targets&IC50
PDE12:9.1 (pIC50)
In vitro
PDE12-IN-1 effectively mitigates the cytopathic effect induced by EMCV in HeLa Ohio cells, demonstrating a potency with a pIC50 of 6.7. Additionally, it suppresses the proliferation of these cells independently of EMCV infection, showing a pIC50 of 5.7. This compound also hampers the growth of both HeLa and HeLaΔPDE12 cells, maintaining the same level of potency (pIC50 of 5.7). Moreover, PDE12-IN-1 showcases its antiviral activity by inhibiting HRV infection with a pIC50 of 6.9[1].
SynonymsPDE12-IN-1
Chemical Properties
Molecular Weight616.491
FormulaC31H27BrFN5O3
Cas No.2259620-80-7
SmilesCCn1cc(-c2nc3cc(Br)c(cc3n2C)C(=O)N2CCO[C@@H]([C@H]2CO)c2ccc(F)cc2)c2ccc(cc12)C#N
Relative Density.1.50 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PDE-12-IN-1PDE12IN1PDE12 IN 1
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