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ZEN-2759

Name: ZEN-2759
Brand: TargetMol
SKU: T70375
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T70375Cas No. 1616400-50-0

ZEN-2759 is a potent BET small molecule inhibitor of BRD4 (BD1), BRD4 (BD2), and BRD4 (BD1BD2).

ZEN-2759

🥰Excellent

Purity: 99.36%

Catalog No. T70375Cas No. 1616400-50-0

ZEN-2759 is a potent BET small molecule inhibitor of BRD4 (BD1), BRD4 (BD2), and BRD4 (BD1BD2).

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$90	In Stock
10 mg	$138	In Stock
25 mg	$232	In Stock
50 mg	$347	In Stock
100 mg	$485	In Stock
200 mg	$687	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.36%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	ZEN-2759 is a potent BET small molecule inhibitor of BRD4 (BD1), BRD4 (BD2), and BRD4 (BD1BD2).
Targets&IC50	BRD4 BD2:0.08 μM, BRD4 BD1:0.23 μM, BRD4 BD1/2:0.28 μM

Chemical Properties

Molecular Weight	280.32
Formula	C₁₇H₁₆N₂O₂
Cas No.	1616400-50-0
Smiles	CC=1C(C2=CN(CC3=CC=CC=C3)C(=O)C=C2)=C(C)ON1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (214.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5674 mL	17.8368 mL	35.6735 mL	178.3676 mL
5 mM	0.7135 mL	3.5674 mL	7.1347 mL	35.6735 mL
10 mM	0.3567 mL	1.7837 mL	3.5674 mL	17.8368 mL
20 mM	0.1784 mL	0.8918 mL	1.7837 mL	8.9184 mL
50 mM	0.0713 mL	0.3567 mL	0.7135 mL	3.5674 mL
100 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc