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Remtolumab
(Synonyms: ABT-122, ABT122, ABT 122) Copy Product Info
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Synonyms: ABT-122, ABT122, ABT 122
Catalog No. T77179 Copy Product Info
Purity: 95%
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Remtolumab is a dual-variable-domain immunoglobulin with low-picomolar Kd affinity for both human TNFα and IL-17. It is used in research related to rheumatoid arthritis, psoriatic arthritis, and moderate to severe plaque psoriasis.
Cas No. 1791410-27-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $498 | - | In Stock | |
| 5 mg | $1,230 | - | In Stock | |
| 10 mg | $1,990 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.8% (SDS-PAGE); 98.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Remtolumab is a dual-variable-domain immunoglobulin with low-picomolar Kd affinity for both human TNFα and IL-17. It is used in research related to rheumatoid arthritis, psoriatic arthritis, and moderate to severe plaque psoriasis. |
| In vitro | Methods: Affinity and potency evaluations were performed on candidate drugs such as Remtolumab, a dual variable domain immunoglobulin (DVD-Ig™), to compare their binding capacity and biological effects on human TNF and human IL-17. Results: As a dominant dual variable domain immunoglobulin (DVD-Ig™) candidate drug, Remtolumab stood out from other candidate drugs of the same type due to its higher affinity and potency for human TNF and human IL-17 [1]. |
| In vivo | Methods: The neutralizing effects of Remtolumab on human TNF and IL-17 were detected in cell and mouse models, and its effects on TNF-Dgal-induced lethal effect and IL-17-induced KC production were observed. Results: Remtolumab could functionally neutralize the activities of human TNF and IL-17, inhibit the lethal effect induced by recombinant human TNF-Dgal, and suppress the production of KC induced by recombinant human IL-17 in mouse models [1]. |
| Synonyms | ABT-122, ABT122, ABT 122 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal, Bispecific |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNF-α |
| Molecular Weight | 198.57 kDa |
| Cas No. | 1791410-27-9 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Remtolumab chemical structure | Remtolumab in vivo | Remtolumab in vitro | Remtolumab molecular weight
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