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CDK1/Cyc B-IN-1

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Catalog No. T61254Cas No. 2459916-56-2

CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, halting cancer cell proliferation, and exhibits a wide-ranging cytotoxic effect on various cancer cell lines [1].

CDK1/Cyc B-IN-1

CDK1/Cyc B-IN-1

😃Good
Catalog No. T61254Cas No. 2459916-56-2
CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, halting cancer cell proliferation, and exhibits a wide-ranging cytotoxic effect on various cancer cell lines [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$2,1406-8 weeks6-8 weeks
50 mg$2,7856-8 weeks6-8 weeks
100 mg$3,5206-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, halting cancer cell proliferation, and exhibits a wide-ranging cytotoxic effect on various cancer cell lines [1].
Targets&IC50
CDK1-CyclinB:97 nM
In vitro
CDK1/Cyc B-IN-1 (Compound 5) exhibits cytotoxic activity with IC50 values of 5.33 ± 0.69 μM against HCT-116 and 21.69 ± 1.04 μM against WI-38 [1].
Chemical Properties
Molecular Weight353.85
FormulaC14H12ClN3O2S2
Cas No.2459916-56-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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