Lonodelestat

Name: Lonodelestat
Brand: TargetMol
SKU: T41043
Rating: 4.5 (1 reviews)

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Catalog No. T41043Cas No. 906547-89-5

Alias POL6014

Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE).

Lonodelestat

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Catalog No. T41043Alias POL6014Cas No. 906547-89-5

Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE).
In vivo	Lonodelestat (POL6014), when intranasally administered to HNE-treated mice, significantly attenuated the inflammatory responses associated with Acute Lung Injury (ALI)[1]. Administered at varying doses (0.1, 0.5, 2, and 10 mg/kg), Lonodelestat demonstrated a dose-dependent decrease in inflammatory markers, prominently reducing the presence of macrophages, epithelial cells, neutrophils, and lymphocytes in bronchoalveolar lavage (BAL). The optimal effect was observed at a dose of 2 mg/kg, achieving a significant reduction in neutrophils (65%, p<0.001), epithelial cells (68%, p<0.001), macrophages (33%, p<0.001), and lymphocytes (77%, p<0.001). The study utilized ten-week-old male C57BL/6j mice, with dosages ranging from 0.05 to 5 mg/kg. Administration took place intranasally 15 minutes prior to HNE exposure (30 UI), effectively mitigating ALI's inflammatory processes[1].
Synonyms	POL6014

Chemical Properties

Molecular Weight	1478.755
Formula	C₇₁H₁₁₁N₁₅O₁₉
Cas No.	906547-89-5
Smiles	[H][C@@]12CCCN1C(=O)[C@@]1([H])CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCCCCC)NC2=O)[C@@H](C)O)[C@@H](C)CC
Sequence	cyclo[Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-D-Pro-Pro-Nle(Bu)(Bu)-Glu-Thr]
Sequence Short	cyclo[ASIPPQKYPPNle(bu)ET]

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc