keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 1,520.00 |
Description | Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). |
In vivo | Lonodelestat (POL6014), when intranasally administered to HNE-treated mice, significantly attenuated the inflammatory responses associated with Acute Lung Injury (ALI)[1]. Administered at varying doses (0.1, 0.5, 2, and 10 mg/kg), Lonodelestat demonstrated a dose-dependent decrease in inflammatory markers, prominently reducing the presence of macrophages, epithelial cells, neutrophils, and lymphocytes in bronchoalveolar lavage (BAL). The optimal effect was observed at a dose of 2 mg/kg, achieving a significant reduction in neutrophils (65%, p<0.001), epithelial cells (68%, p<0.001), macrophages (33%, p<0.001), and lymphocytes (77%, p<0.001). The study utilized ten-week-old male C57BL/6j mice, with dosages ranging from 0.05 to 5 mg/kg. Administration took place intranasally 15 minutes prior to HNE exposure (30 UI), effectively mitigating ALI's inflammatory processes[1]. |
Synonyms | POL6014 |
Molecular Weight | 1478.755 |
Formula | C71H111N15O19 |
CAS No. | 906547-89-5 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Lonodelestat 906547-89-5 POL-6014 POL 6014 POL6014 inhibitor inhibit