Lonodelestat

Name: Lonodelestat
Brand: TargetMol
SKU: T41043
Rating: 4.5 (1 reviews)

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Catalog No. T41043Cas No. 906547-89-5

Alias POL6014

Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE).

Lonodelestat

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Catalog No. T41043Alias POL6014Cas No. 906547-89-5

Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE).
In vivo	Lonodelestat (POL6014), when intranasally administered to HNE-treated mice, significantly attenuated the inflammatory responses associated with Acute Lung Injury (ALI)[1]. Administered at varying doses (0.1, 0.5, 2, and 10 mg/kg), Lonodelestat demonstrated a dose-dependent decrease in inflammatory markers, prominently reducing the presence of macrophages, epithelial cells, neutrophils, and lymphocytes in bronchoalveolar lavage (BAL). The optimal effect was observed at a dose of 2 mg/kg, achieving a significant reduction in neutrophils (65%, p<0.001), epithelial cells (68%, p<0.001), macrophages (33%, p<0.001), and lymphocytes (77%, p<0.001). The study utilized ten-week-old male C57BL/6j mice, with dosages ranging from 0.05 to 5 mg/kg. Administration took place intranasally 15 minutes prior to HNE exposure (30 UI), effectively mitigating ALI's inflammatory processes[1].
Synonyms	POL6014

Chemical Properties

Molecular Weight	1478.755
Formula	C₇₁H₁₁₁N₁₅O₁₉
Cas No.	906547-89-5
Smiles	[H][C@@]12CCCN1C(=O)[C@@]1([H])CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCCCCC)NC2=O)[C@@H](C)O)[C@@H](C)CC
Sequence Short	cyclo[ASIPPQKYPPNle(bu)ET]

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc