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Anti-GFR Alpha-3/GFRA3 Antibody (2U985)
😃Good
Catalog No. TMAY-00474
Alias Y15110, GFRα3, GFRalpha3, GFR α-3/GFRA3, GDNF family receptor α3, GDNF family receptor alpha 3
Anti-GFR Alpha-3/GFRA3 Antibody (2U985) is a Rabbit antibody targeting GFR Alpha-3/GFRA3. Anti-GFR Alpha-3/GFRA3 Antibody (2U985) can be used in ELISA.
Anti-GFR Alpha-3/GFRA3 Antibody (2U985)
Anti-GFR Alpha-3/GFRA3 Antibody (2U985)
😃Good
Catalog No. TMAY-00474Alias Y15110, GFRα3, GFRalpha3, GFR α-3/GFRA3, GDNF family receptor α3, GDNF family receptor alpha 3
Anti-GFR Alpha-3/GFRA3 Antibody (2U985) is a Rabbit antibody targeting GFR Alpha-3/GFRA3. Anti-GFR Alpha-3/GFRA3 Antibody (2U985) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | Y15110, GFRα3, GFRalpha3, GFR α-3/GFRA3, GDNF family receptor α3, GDNF family receptor alpha 3 |
| Ig Type | Rabbit IgG |
| Clone | 2U985 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA3 (rh GFRA3; TMPY-01458; NP_001487.2; Met 1-Trp 382). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human GFRA3 protein (TMPY-01458) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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