SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH) that exhibits antifungal activity against Botrytis cinerea with an EC50 of 2.7 μg/mL. It functions by disrupting the integrity of cell walls and cell membranes.

SDH-IN-14 exhibits various effects on Botrytis cinerea, with treatment concentrations ranging from 0-100 μg/mL over 12 hours leading to increased cell membrane permeability. At concentrations of 0-200 μg/mL for 10 hours, it causes elevated MDA levels due to oxidative damage to the cell membrane. Furthermore, SDH-IN-14, at 12.5-100 μg/mL over 24 hours, shows a dose-dependent inhibition of SDH activity. The antifungal inhibition rates of SDH-IN-14 at 100 μg/mL are reported as 96.7% against B.cinerea, 52.6% against R.solani, 69.9% against P.capsici, 59.2% against S.sclerotiorum, 34.5% against F.graminearum, 70.6% against Tomato Botrytis cinerea, and 15.0% against F.asiaticum.

SDH-IN-14, at concentrations of 100 and 200 μg/mL, demonstrates excellent antifungal activity on blueberry leaves, surpassing the effectiveness of Azoxystrobin and Fluopyram.