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PROTACs

PROteolysis TArgeting Chimeras (PROTACs) achieve degradation through "hijacking" the cell's ubiquitin–proteasome system (UPS) by bringing together the target protein and an E3 ligase. Because PROTACs need only to bind their targets with high selectivity (rather than inhibit the target protein's enzymatic activity), there are currently many efforts to retool previously ineffective inhibitor molecules as PROTACs for next-generation drugs.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T14908 CCT367766 2229856-58-8 100%
CCT367766
CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concen...
T16667 PROTAC Sirt2 Degrader-1 2098487-75-1 98%
PROTAC Sirt2 Degrader-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
T40121 SHP2-D26 2458219-65-1 98%
SHP2-D26
SHP2-D26 is a highly potent and effective SHP2 degrader. Its mechanism of action involves the induction of SHP2 degradation through binding to VHL-1 and SHP2 pro...
T40143 PROTAC CBP/P300 Degrader-1 2484739-48-0 98%
PROTAC CBP/P300 Degrader-1
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lin...
T17249 VZ185 2306193-61-1 98%
VZ185
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
T11292 FKBP12 PROTAC dTAG-7 2064175-32-0 98%
FKBP12 PROTAC dTAG-7
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET ...
T5438 PROTAC CDK9 Degrader-1 2118356-96-8 98%
PROTAC CDK9 Degrader-1
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
T13839 PROTAC ER Degrader-4 2361114-15-8 98%
PROTAC ER Degrader-4
PROTAC ER Degrader-4 is a PROATC degrader of estrogen receptor (ER)(IC50 of 0.8 nM).
T11664 INY-03-041 98%
INY-03-041
INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Th...
T12556 PROTAC B-Raf degrader 1 2364367-27-9 98%
PROTAC B-Raf degrader 1
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
T39929 MS21 2376137-05-0 98%
MS21
MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.
T77913 PZ703b TFA 98%
PZ703b TFA
PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound for r...
T77915 CCT367766 formic 98%
CCT367766 formic
CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for deg...
T77920 ZXH-4-130 TFA 2711006-67-4 98%
ZXH-4-130 TFA
ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN. At a concentration of 10 nM in MM1.S ce...
T77922 HDAC6 degrader-1 2439058-23-6 98%
HDAC6 degrader-1
HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linke...
T77923 BSJ-03-204 triTFA 98%
BSJ-03-204 triTFA
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degrada...
T77924 SB1-G-187 2769753-18-4 98%
SB1-G-187
SB1-G-187 is a PROTAC (PROteolysis TArgeting Chimera) that functions as a multi-kinase degrader [1].
T77925 DB-0646 98%
DB-0646
DB-0646 is a PROTAC designed to induce the degradation of multiple kinases.
T77926 PROTAC KRAS G12C degrader-1 98%
PROTAC KRAS G12C degrader-1
PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells [...
T77929 Dovitinib-RIBOTAC 2759351-68-1 98%
Dovitinib-RIBOTAC
Dovitinib RIBOTAC is a potent, selective targeted RNA degrader that cleaves pre-miR-21.
CCT367766
T14908
CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concen...
PROTAC Sirt2 Degrader-1
T16667
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
SHP2-D26
T40121
SHP2-D26 is a highly potent and effective SHP2 degrader. Its mechanism of action involves the induction of SHP2 degradation through binding to VHL-1 and SHP2 pro...
PROTAC CBP/P300 Degrader-1
T40143
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lin...
VZ185
T17249
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
FKBP12 PROTAC dTAG-7
T11292
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET ...
PROTAC CDK9 Degrader-1
T5438
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
PROTAC ER Degrader-4
T13839
PROTAC ER Degrader-4 is a PROATC degrader of estrogen receptor (ER)(IC50 of 0.8 nM).
INY-03-041
T11664
INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Th...
PROTAC B-Raf degrader 1
T12556
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
MS21
T39929
MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.
PZ703b TFA
T77913
PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound for r...
CCT367766 formic
T77915
CCT367766 formic is a potent third-generation heterobifunctional Cereblon-based protein degradation probe (PDP, or PROTAC) that selectively targets pirin for deg...
ZXH-4-130 TFA
T77920
ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN. At a concentration of 10 nM in MM1.S ce...
HDAC6 degrader-1
T77922
HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linke...
BSJ-03-204 triTFA
T77923
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degrada...
SB1-G-187
T77924
SB1-G-187 is a PROTAC (PROteolysis TArgeting Chimera) that functions as a multi-kinase degrader [1].
DB-0646
T77925
DB-0646 is a PROTAC designed to induce the degradation of multiple kinases.
PROTAC KRAS G12C degrader-1
T77926
PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells [...
Dovitinib-RIBOTAC
T77929
Dovitinib RIBOTAC is a potent, selective targeted RNA degrader that cleaves pre-miR-21.
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