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Raxatrigine hydrochloride (Synonyms: GSK-1014802 hydrochloride, CNV1014802 (hydrochloride))

Name: Raxatrigine hydrochloride
Brand: TargetMol
SKU: T14992
Rating: 4.5 (1 reviews)

Catalog No. T14992 Copy Product Info

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Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.

Raxatrigine hydrochloride

Copy Product Info

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Catalog No. T14992

Synonyms GSK-1014802 hydrochloride, CNV1014802 (hydrochloride)

Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.

Cas No. 934240-31-0

Pack Size	Price	USA Stock	Global Stock
2 mg	$88	5 days	5 days
5 mg	$178	5 days	5 days
25 mg	$652	1-2 weeks	1-2 weeks
50 mg	$847	1-2 weeks	1-2 weeks
100 mg	$1,340	1-2 weeks	1-2 weeks
1 mL x 10 mM (in DMSO)	$176	5 days	5 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.
Synonyms	GSK-1014802 hydrochloride, CNV1014802 (hydrochloride)

Chemical Properties

Molecular Weight	350.82
Formula	C₁₈H₂₀ClFN₂O₂
Cas No.	934240-31-0
Smiles	Cl.NC(=O)[C@@H]1CC[C@@H](N1)c1ccc(OCc2ccccc2F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31 mg/mL (88.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8505 mL	14.2523 mL	28.5046 mL	142.5232 mL
5 mM	0.5701 mL	2.8505 mL	5.7009 mL	28.5046 mL
10 mM	0.2850 mL	1.4252 mL	2.8505 mL	14.2523 mL
20 mM	0.1425 mL	0.7126 mL	1.4252 mL	7.1262 mL
50 mM	0.0570 mL	0.2850 mL	0.5701 mL	2.8505 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc