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WIN 54954

Name: WIN 54954
Brand: TargetMol
SKU: T61652
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61652Cas No. 107355-45-3

WIN 54954 is an orally available antiviral agent that inhibits Coxsackievirus and inhibits viral translation or transcription.WIN 54954 may be useful in the study of small ribonucleic acid virus infections.

WIN 54954

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Purity: 98.98%

Catalog No. T61652Cas No. 107355-45-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	-	In Stock
5 mg	$108	-	In Stock
10 mg	$177	-	In Stock
25 mg	$322	-	In Stock
50 mg	$517	-	In Stock
100 mg	$828	-	In Stock
1 mL x 10 mM (in DMSO)	$122	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.98%

Appearance:Oil

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	WIN 54954 is an orally available antiviral agent that inhibits Coxsackievirus and inhibits viral translation or transcription.WIN 54954 may be useful in the study of small ribonucleic acid virus infections.
In vitro	WIN 54954 reduced plaque formation by 50 of 52 serotypes of rhinovirus (MIC range: 0.007 to 2.2 μg/ml). A concentration of 0.28 μg/ml effectively inhibited 80% of the 52 serotypes (EC80). WIN 54954 also effectively inhibited 15 commonly isolated enteroviruses, with an EC80 of 0.06 μg/ml[1].
In vivo	A single gastric dose of WIN 54954 at daily doses of 2 and 100 mg/kg protected 50% of mice from paralysis after infection with Coxsackie virus A-9 and ECHO virus-9, respectively (PD50)[1].

Chemical Properties

Molecular Weight	383.27
Formula	C₁₈H₂₀Cl₂N₂O₃
Cas No.	107355-45-3
Smiles	Cc1cc(CCCCCOc2c(Cl)cc(cc2Cl)C2=NCCO2)on1

Storage & Solubility Information

Storage

keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (208.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6091 mL	13.0456 mL	26.0913 mL	130.4563 mL
5 mM	0.5218 mL	2.6091 mL	5.2183 mL	26.0913 mL
10 mM	0.2609 mL	1.3046 mL	2.6091 mL	13.0456 mL
20 mM	0.1305 mL	0.6523 mL	1.3046 mL	6.5228 mL
50 mM	0.0522 mL	0.2609 mL	0.5218 mL	2.6091 mL
100 mM	0.0261 mL	0.1305 mL	0.2609 mL	1.3046 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc