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Tafluprost

Name: Tafluprost
Brand: TargetMol
SKU: TQ0203
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0203Cas No. 209860-87-7

Alias MK2452, AFP-168

Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.

Tafluprost

🥰Excellent

Purity: 99.67%

Catalog No. TQ0203Alias MK2452, AFP-168Cas No. 209860-87-7

Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$51	In Stock
10 mg	$79	In Stock
25 mg	$142	In Stock
50 mg	$216	In Stock
100 mg	$322	In Stock
200 mg	$479	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock

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Purity:99.67%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
In vivo	Tafluprost showed significant IOP-lowering effects without any safety concerns in patients with various types of glaucoma and OH in daily clinical practice and tafluprost is highly effective in any therapeutic pattern [1]. Tafluprost with reduced BAK has potential as a superior antiglaucoma drug, not only for its IOP-lowering effect but also for its good corneal safety profile [2]. Tafluprost single-use vials treatment was effective in reducing IOP over the 3 years of this study, but visual field performance worsened by 10.3%-13.8% in patients with normal-tension glaucoma [3].
Synonyms	MK2452, AFP-168

Chemical Properties

Molecular Weight	452.53
Formula	C₂₅H₃₄F₂O₅
Cas No.	209860-87-7
Smiles	CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COc1ccccc1
Relative Density.	1.186 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (552.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2098 mL	11.0490 mL	22.0980 mL	110.4899 mL
5 mM	0.4420 mL	2.2098 mL	4.4196 mL	22.0980 mL
10 mM	0.2210 mL	1.1049 mL	2.2098 mL	11.0490 mL
20 mM	0.1105 mL	0.5524 mL	1.1049 mL	5.5245 mL
50 mM	0.0442 mL	0.2210 mL	0.4420 mL	2.2098 mL
100 mM	0.0221 mL	0.1105 mL	0.2210 mL	1.1049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc