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Thiodigalactoside

Name: Thiodigalactoside
Brand: TargetMol
SKU: T38074
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38074Cas No. 51555-87-4

Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.

Thiodigalactoside

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Purity: 99.90%

Catalog No. T38074Cas No. 51555-87-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$52	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$33	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.90%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.
Targets&IC50	GAL3:49 μM (Kd), GAL1:24 μM (Kd)
In vitro	Thiodigalactoside (TDG; 250 and 500 μM) demonstrates a dose-dependent decrease in fat accumulation, as evidenced by reductions in triglyceride (TG) content and Oil Red O (ORO) staining[1].
In vivo	Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) significantly inhibits HFD-induced body weight gain, whereas oral administration (5 mg/kg; daily or weekly for 5 weeks) provides less reduction in body weight gain compared to IP administration [2].

Chemical Properties

Molecular Weight	358.36
Formula	C₁₂H₂₂O₁₀S
Cas No.	51555-87-4
Smiles	OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 10 mg/mL (27.9 mM), Sonication is recommended.

H2O: 90 mg/mL (251.14 mM), Sonication is recommended.

DMF: 1 mg/mL (2.79 mM), Sonication is recommended.

DMSO: 50 mg/mL (139.52 mM), Sonication is recommended.

Solution Preparation Table

DMF/PBS (pH 7.2)/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.7905 mL	13.9525 mL	27.9049 mL	139.5245 mL

PBS (pH 7.2)/DMSO/H2O

	1mg	5mg	10mg	50mg
5 mM	0.5581 mL	2.7905 mL	5.5810 mL	27.9049 mL
10 mM	0.2790 mL	1.3952 mL	2.7905 mL	13.9525 mL
20 mM	0.1395 mL	0.6976 mL	1.3952 mL	6.9762 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
50 mM	0.0558 mL	0.2790 mL	0.5581 mL	2.7905 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3952 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc