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Anti-CD137 Polyclonal Antibody

Catalog No. TMAB-03845 Copy Product Info
🥰Excellent
Anti-CD137 Polyclonal Antibody is a Rabbit antibody targeting CD137. Anti-CD137 Polyclonal Antibody can be used in WB.

Anti-CD137 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-03845

Anti-CD137 Polyclonal Antibody is a Rabbit antibody targeting CD137. Anti-CD137 Polyclonal Antibody can be used in WB.

Anti-CD137 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2217-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5287-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-CD137 Polyclonal Antibody is a Rabbit antibody targeting CD137. Anti-CD137 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse
Verified Activity
1. Sample:
HepG2 (Human) Cell Lysate at 30 μg
Primary: Anti-CD137 (TMAB-03845) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25 kD
Observed band size: 39 kD
2. Sample:
Lane 1: Mouse Thymus Lysates
Lane 2: Mouse Spleen Lysates
Lane 2: Mouse Lymph Lysates
Primary: Anti-CD137 (TMAB-03845) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25 kDa
Observed band size: 42 kDa
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue SpecificityExpressed on the surface of activated T-cells.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundCD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human CD137
Antigen Species
Human
Gene Name
TNFRSF9
Gene ID
3604
Protein Name
Tumor necrosis factor receptor superfamily member 9
Uniprot ID
Q07011
Function
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Chemical Properties
Molecular WeightTheoretical: 25 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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