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SID 3712249

Name: SID 3712249
Brand: TargetMol
SKU: T16882
Rating: 4.5 (1 reviews)

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Catalog No. T16882Cas No. 522606-67-3

Alias MiR-544 Inhibitor 1

SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).

SID 3712249

😃Good

Catalog No. T16882Alias MiR-544 Inhibitor 1Cas No. 522606-67-3

SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$48	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).
In vitro	MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple-negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantation into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking the production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
Synonyms	MiR-544 Inhibitor 1

Chemical Properties

Molecular Weight	323.4
Formula	C₁₇H₂₁N₇
Cas No.	522606-67-3
Smiles	Nc1nc(cc2c(C#N)c(nc(N)c12)N1CCCC1)N1CCCC1
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (51.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0921 mL	15.4607 mL	30.9215 mL	154.6073 mL
5 mM	0.6184 mL	3.0921 mL	6.1843 mL	30.9215 mL
10 mM	0.3092 mL	1.5461 mL	3.0921 mL	15.4607 mL
20 mM	0.1546 mL	0.7730 mL	1.5461 mL	7.7304 mL
50 mM	0.0618 mL	0.3092 mL	0.6184 mL	3.0921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc