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Natalizumab
Catalog No. T12177 Copy Product Info
Purity: 98.00%
🥰Excellent
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
Natalizumab
Copy Product Info🥰Excellent
Catalog No. T12177
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
Cas No. 189261-10-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $147 | In Stock | In Stock | |
| 2 mg | $229 | - | In Stock | |
| 5 mg | $413 | - | In Stock | |
| 10 mg | $662 | - | In Stock | |
| 25 mg | $987 | - | In Stock | |
| 50 mg | $1,330 | - | In Stock | |
| 100 mg | $1,790 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.00%
Appearance:Liquid
Color:Transparent
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| Description | Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. |
| Targets&IC50 | α4β1/α4β7 - MadCAM-1-Ig:0.35 ± 0.04 nM, α4β1:0.11 ± 0.01 μg/mL (EC50), α4β1:19.6 nM (KD), α4β1/α4β7 - Fibronectin:0.32 nM, α4β1/α4β7 - VCAM-1-Ig:0.196 nM |
| In vitro | Natalizumab, a new disease-modifying therapy for relapsing remitting multiple sclerosis (RRMS), is a humanized monoclonal antibody which binds to alpha(4)beta(1)-integrin.As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin[1]. |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Integrin a4/ITGA4/CD49d |
| Molecular Weight | 146.19 kDa |
| Cas No. | 189261-10-7 |
| Relative Density. | no data available |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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