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Anti-Phospho-CRK (Ser41) Polyclonal Antibody
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Catalog No. TMAB-10543
Anti-Phospho-CRK (Ser41) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRK (Ser41). Anti-Phospho-CRK (Ser41) Polyclonal Antibody can be used in WB.
Anti-Phospho-CRK (Ser41) Polyclonal Antibody
Anti-Phospho-CRK (Ser41) Polyclonal Antibody
😃Good
Catalog No. TMAB-10543
Anti-Phospho-CRK (Ser41) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRK (Ser41). Anti-Phospho-CRK (Ser41) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-CRK (Ser41) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRK (Ser41). Anti-Phospho-CRK (Ser41) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human CRK around the phosphorylation site of Ser41 |
| Antigen Species | Human |
| Gene Name | CRK |
| Gene ID | |
| Protein Name | Adapter molecule crk |
| Uniprot ID | |
| Function | The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
| Molecular Weight | Theoretical: 34 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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