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Anti-Phospho-CRK (Ser41) Polyclonal Antibody

Catalog No. TMAB-10543 Copy Product Info
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Anti-Phospho-CRK (Ser41) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRK (Ser41). Anti-Phospho-CRK (Ser41) Polyclonal Antibody can be used in WB.

Anti-Phospho-CRK (Ser41) Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-10543

Anti-Phospho-CRK (Ser41) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRK (Ser41). Anti-Phospho-CRK (Ser41) Polyclonal Antibody can be used in WB.

Anti-Phospho-CRK
(Ser41) Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2207-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5297-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Phospho-CRK (Ser41) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRK (Ser41). Anti-Phospho-CRK (Ser41) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Dog,Pig,Horse,Rabbit,Sheep)
Verified Activity
Sample: k562 (human) Cell Lysate at 30 μg
Primary: Anti-phospho-CRK (Ser41) (TMAB-10543) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 34 kD
Observed band size: 34 kD
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human CRK around the phosphorylation site of Ser41
Antigen Species
Human
Gene Name
CRK
Gene ID
Protein Name
Adapter molecule crk
Uniprot ID
Function
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Chemical Properties
Molecular WeightTheoretical: 34 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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