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IPI-3063

Name: IPI-3063
Brand: TargetMol
SKU: T15592
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15592Cas No. 1425043-73-7

IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).

IPI-3063

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Purity: 98.00%

Catalog No. T15592Cas No. 1425043-73-7

IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$58	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$178	In Stock	In Stock
25 mg	$358	In Stock	In Stock
50 mg	$497	In Stock	In Stock
100 mg	$678	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$115	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.00%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
Targets&IC50	p110α:1170 nM, p110γ:2187 nM, p110β:1508 nM, p110δ:2.5 nM
In vitro	IPI-3063 is a p110δ selective compound with an IC50=0.1?nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very effective in reducing p-AKT (significant effect at 1?nM) and it also decreases p-ERK1/2 with a significant effect at 10?nM. IPI-3063 is very effective, achieving a significant decrease in B cell survival when present at 10?nM and it also inhibits p110α, p110β, and p110γ (IC50s: 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively). IPI-3063 effectively decreases mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1.

Chemical Properties

Molecular Weight	455.51
Formula	C₂₅H₂₅N₇O₂
Cas No.	1425043-73-7
Smiles	CC(C)n1c(cc2cccc(-c3ccc(=O)n(C)c3)c2c1=O)[C@H](C)Nc1ncnc(N)c1C#N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (182.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1953 mL	10.9767 mL	21.9534 mL	109.7671 mL
5 mM	0.4391 mL	2.1953 mL	4.3907 mL	21.9534 mL
10 mM	0.2195 mL	1.0977 mL	2.1953 mL	10.9767 mL
20 mM	0.1098 mL	0.5488 mL	1.0977 mL	5.4884 mL
50 mM	0.0439 mL	0.2195 mL	0.4391 mL	2.1953 mL
100 mM	0.0220 mL	0.1098 mL	0.2195 mL	1.0977 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc