Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

NDT-19795

Name: NDT-19795
Brand: TargetMol
SKU: T86987
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T86987Cas No. 2272917-12-9

Alias NDT-19795, NDT19795, NDT 19795

NDT-19795 is an effective small-molecule inhibitor of the NLRP3 inflammasome with IC50 values of 66 nM in PBMC-based assays and 4.7 μM in western blot analyses, functioning as a carboxylic acid–active metabolite derived intracellularly from NT-0796, and supporting research into neuroinflammation and neurological disease mechanisms.

NDT-19795

Copy Product Info

😃Good

Catalog No. T86987Alias NDT-19795, NDT19795, NDT 19795Cas No. 2272917-12-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$98	10-14 weeks	10-14 weeks
5 mg	Preferential	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	NDT-19795 is an effective small-molecule inhibitor of the NLRP3 inflammasome with IC50 values of 66 nM in PBMC-based assays and 4.7 μM in western blot analyses, functioning as a carboxylic acid–active metabolite derived intracellularly from NT-0796, and supporting research into neuroinflammation and neurological disease mechanisms.
Targets&IC50	NLRP3:66 nM
In vivo	Method: NDT-19795 was administered intravenously at 3 mg/kg as a single dose in C57BL/6 mice. Result: NDT-19795 showed a low brain-to-blood ratio of 0.07, indicating limited BBB penetration[1].
Synonyms	NDT-19795, NDT19795, NDT 19795

Chemical Properties

Molecular Weight	367.4
Formula	C₂₀H₂₁N₃O₄
Cas No.	2272917-12-9
Smiles	N(C(O[C@H](CC=1N=CC=CN1)C(O)=O)=O)C2=C3C(=CC4=C2CCC4)CCC3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80.00 mg/mL (217.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7218 mL	13.6091 mL	27.2183 mL	136.0915 mL
5 mM	0.5444 mL	2.7218 mL	5.4437 mL	27.2183 mL
10 mM	0.2722 mL	1.3609 mL	2.7218 mL	13.6091 mL
20 mM	0.1361 mL	0.6805 mL	1.3609 mL	6.8046 mL
50 mM	0.0544 mL	0.2722 mL	0.5444 mL	2.7218 mL
100 mM	0.0272 mL	0.1361 mL	0.2722 mL	1.3609 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

NDT-19795

NDT-19795

Featured Recommendations

Batch Information

Resource Download

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Tech Support