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NDT-19795
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Catalog No. T86987Cas No. 2272917-12-9
Alias NDT-19795, NDT19795, NDT 19795
NDT-19795 is an effective small-molecule inhibitor of the NLRP3 inflammasome with IC50 values of 66 nM in PBMC-based assays and 4.7 μM in western blot analyses, functioning as a carboxylic acid–active metabolite derived intracellularly from NT-0796, and supporting research into neuroinflammation and neurological disease mechanisms.
NDT-19795
😃Good
Catalog No. T86987Alias NDT-19795, NDT19795, NDT 19795Cas No. 2272917-12-9
NDT-19795 is an effective small-molecule inhibitor of the NLRP3 inflammasome with IC50 values of 66 nM in PBMC-based assays and 4.7 μM in western blot analyses, functioning as a carboxylic acid–active metabolite derived intracellularly from NT-0796, and supporting research into neuroinflammation and neurological disease mechanisms.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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| Description | NDT-19795 is an effective small-molecule inhibitor of the NLRP3 inflammasome with IC50 values of 66 nM in PBMC-based assays and 4.7 μM in western blot analyses, functioning as a carboxylic acid–active metabolite derived intracellularly from NT-0796, and supporting research into neuroinflammation and neurological disease mechanisms. |
| Targets&IC50 | NLRP3:66 nM |
| In vivo | Method: NDT-19795 was administered intravenously at 3 mg/kg as a single dose in C57BL/6 mice. Result: NDT-19795 showed a low brain-to-blood ratio of 0.07, indicating limited BBB penetration[1]. |
| Synonyms | NDT-19795, NDT19795, NDT 19795 |
| Molecular Weight | 367.4 |
| Formula | C20H21N3O4 |
| Cas No. | 2272917-12-9 |
| Smiles | N(C(O[C@H](CC=1N=CC=CN1)C(O)=O)=O)C2=C3C(=CC4=C2CCC4)CCC3 |
| Color | White |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (217.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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