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Mitiperstat

Name: Mitiperstat
Brand: TargetMol
SKU: T61028
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61028Cas No. 1933460-19-5

Alias AZD4831

Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease.

Mitiperstat

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Purity: 98.36%

Catalog No. T61028Alias AZD4831Cas No. 1933460-19-5

Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$158	In Stock	In Stock
5 mg	$396	In Stock	In Stock
10 mg	$479	In Stock	In Stock
25 mg	$778	In Stock	In Stock
50 mg	$987	-	In Stock
100 mg	$1,380	-	In Stock
1 mL x 10 mM (in DMSO)	$436	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.36%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease.
In vivo	AZD4831 (5 mg) inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models.[2]
Synonyms	AZD4831

Chemical Properties

Molecular Weight	334.82
Formula	C₁₅H₁₅ClN₄OS
Cas No.	1933460-19-5
Smiles	C(N1C2=C(C(=O)NC1=S)NC=C2)C3=C([C@@H](C)N)C=C(Cl)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 135 mg/mL (403.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9867 mL	14.9334 mL	29.8668 mL	149.3340 mL
5 mM	0.5973 mL	2.9867 mL	5.9734 mL	29.8668 mL
10 mM	0.2987 mL	1.4933 mL	2.9867 mL	14.9334 mL
20 mM	0.1493 mL	0.7467 mL	1.4933 mL	7.4667 mL
50 mM	0.0597 mL	0.2987 mL	0.5973 mL	2.9867 mL
100 mM	0.0299 mL	0.1493 mL	0.2987 mL	1.4933 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc