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Escitalopram
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Catalog No. T0185Cas No. 128196-01-0
Alias Seroplex, S-(+)-Citalopram, (S)-Citalopram
Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
Escitalopram
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Purity: 99.82%
Catalog No. T0185Alias Seroplex, S-(+)-Citalopram, (S)-CitalopramCas No. 128196-01-0
Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $40 | In Stock | In Stock | |
| 10 mg | $56 | In Stock | In Stock | |
| 25 mg | $113 | In Stock | In Stock | |
| 50 mg | $179 | In Stock | In Stock | |
| 100 mg | $272 | In Stock | In Stock | |
| 200 mg | $396 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.82%
Appearance:Oil
Color:Transparent
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Product Introduction
Escitalopram AI Summary
Escitalopram exhibits a diverse range of bioactivities, demonstrating high oral bioavailability in humans at 80.0%. It acts as a potent inhibitor of the human serotonin transporter (SERT) with Ki values ranging from 0.89 nM to 2.2 nM and shows additional affinity for norepinephrine transporter (NET) and dopamine transporter (DAT) at significantly higher Ki values. It also functions as a potent SERT allosteric modulator, inhibiting [3H]citalopram dissociation with IC50 values indicating strong impact. The compound presents notable antidepressant-like activity in rodents, evidenced by reduced immobility time in forced swim tests and increased extracellular serotonin levels in the hippocampus.
Furthermore, Escitalopram exhibits selective binding and inhibition of multiple cytochrome P450 enzymes and shows anti-stress effects in rat models under chronic mild stress. It displays high solubility and favorable distribution coefficient logD7.4, ensuring permeability and potential systemic reach. The compound also demonstrates brain equilibration and active transport mechanisms, indicating broad pharmacological utility.
In terms of antiviral properties, Escitalopram shows activity against SARS-CoV-2 by inhibiting cytotoxicity in various cell lines and moderately inhibits the SARS-CoV-2 3CL-pro protease activity. However, it has been associated with potential hepatotoxicity and variable effects on cell viability across different cell types. Its mixed impact on protein thermal stability suggests domain-specific interactions.
Overall, Escitalopram appears to be a promising pharmacological candidate with significant neurotransmitter transporter affinity, antidepressant effects, and potential antiviral capabilities, albeit with considerations for its safety profile and biological selectivity..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition. |
| Targets&IC50 | SSRI:0.89 nM(ki) |
| Synonyms | Seroplex, S-(+)-Citalopram, (S)-Citalopram |
| Molecular Weight | 324.39 |
| Formula | C20H21FN2O |
| Cas No. | 128196-01-0 |
| Smiles | C(CCN(C)C)[C@@]1(C=2C(CO1)=CC(C#N)=CC2)C3=CC=C(F)C=C3 |
| Relative Density. | 1.18 g/cm3 |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (770.68 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.17 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α-adrenergic receptorSLC6A4Sert (Sodium-dependent)SERTSerotoninTransporterSerotonin TransporterS-enantiomerselectivityS-CitalopramreuptakeNoradrenaline transporter (Sodium-dependent)mAChRInhibitorinhibitimpairmentsHistamineReceptorHistamine ReceptorH1 receptorEscitalopramDopamineReceptorDopamine ReceptordepressionDA transportercognitiveCitalopramantidepressantAdrenergicReceptorAdrenergic Receptor5-HTT5HTReceptor5HT Receptor
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