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SB-277011 hydrochloride

Name: SB-277011 hydrochloride
Brand: TargetMol
SKU: T63096
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63096Cas No. 215804-67-4

Alias SB-277011A hydrochloride, SB 277011A hydrochloride, SB 277011 hydrochloride

SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, and orally active dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier, with Ki values of 10.7 nM for rodent D3R and 11.2 nM for human D3R. It is 80-100 times more selective for D3 receptors than other dopamine receptors, acting on D3 receptors (pKi: 8.0), D2 receptors (pKi: 6.0), 5-HT1B receptors (pKi < 5.2), and 5-HT1D receptors (pKi: 5.9).

SB-277011 hydrochloride

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Purity: 98.54%

Catalog No. T63096Alias SB-277011A hydrochloride, SB 277011A hydrochloride, SB 277011 hydrochlorideCas No. 215804-67-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$46	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.54%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, and orally active dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier, with Ki values of 10.7 nM for rodent D3R and 11.2 nM for human D3R. It is 80-100 times more selective for D3 receptors than other dopamine receptors, acting on D3 receptors (pKi: 8.0), D2 receptors (pKi: 6.0), 5-HT1B receptors (pKi < 5.2), and 5-HT1D receptors (pKi: 5.9).
Targets&IC50	D3 receptor:10.7-11.2 nM (Ki)
In vivo	SB 2770119 inhibited the development of haloperidol-induced catalepsy in a dose-dependent manner over a dose range of 13.5-30 mg/kg p.o. [2] SB-277011 (1-12 mg/kg, ip) dose-dependently reduces nicotine-enhanced BSR, nicotine-induced conditioned LMA, and nicotine-induced CPP. [3]
Synonyms	SB-277011A hydrochloride, SB 277011A hydrochloride, SB 277011 hydrochloride

Chemical Properties

Molecular Weight	475.03
Formula	C₂₈H₃₁ClN₄O
Cas No.	215804-67-4
Smiles	C(N[C@@H]1CC[C@@H](CCN2CC=3C(CC2)=CC(C#N)=CC3)CC1)(=O)C=4C5=C(N=CC4)C=CC=C5.Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (21.05 mM), Sonication is recommended.

DMSO: 40 mg/mL (84.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1051 mL	10.5257 mL	21.0513 mL	105.2565 mL
5 mM	0.4210 mL	2.1051 mL	4.2103 mL	21.0513 mL
10 mM	0.2105 mL	1.0526 mL	2.1051 mL	10.5257 mL
20 mM	0.1053 mL	0.5263 mL	1.0526 mL	5.2628 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0421 mL	0.2105 mL	0.4210 mL	2.1051 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc