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SB-277011 hydrochloride

Name: SB-277011 hydrochloride
Brand: TargetMol
SKU: T63096
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T63096Cas No. 215804-67-4

Alias SB-277011A hydrochloride, SB 277011A hydrochloride, SB 277011 hydrochloride

SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, and orally active dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier, with Ki values of 10.7 nM for rodent D3R and 11.2 nM for human D3R. It is 80-100 times more selective for D3 receptors than other dopamine receptors, acting on D3 receptors (pKi: 8.0), D2 receptors (pKi: 6.0), 5-HT1B receptors (pKi < 5.2), and 5-HT1D receptors (pKi: 5.9).

SB-277011 hydrochloride

🥰Excellent

Purity: 98.54%

Catalog No. T63096Alias SB-277011A hydrochloride, SB 277011A hydrochloride, SB 277011 hydrochlorideCas No. 215804-67-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$46	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.54%

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COA LCMS

Product Introduction

Bioactivity

Description	SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, and orally active dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier, with Ki values of 10.7 nM for rodent D3R and 11.2 nM for human D3R. It is 80-100 times more selective for D3 receptors than other dopamine receptors, acting on D3 receptors (pKi: 8.0), D2 receptors (pKi: 6.0), 5-HT1B receptors (pKi < 5.2), and 5-HT1D receptors (pKi: 5.9).
Targets&IC50	D3 receptor:10.7-11.2 nM (Ki)
In vivo	SB 2770119 inhibited the development of haloperidol-induced catalepsy in a dose-dependent manner over a dose range of 13.5-30 mg/kg p.o. [2] SB-277011 (1-12 mg/kg, ip) dose-dependently reduces nicotine-enhanced BSR, nicotine-induced conditioned LMA, and nicotine-induced CPP. [3]
Synonyms	SB-277011A hydrochloride, SB 277011A hydrochloride, SB 277011 hydrochloride

Chemical Properties

Molecular Weight	475.03
Formula	C₂₈H₃₁ClN₄O
Cas No.	215804-67-4
Smiles	C(N[C@@H]1CC[C@@H](CCN2CC=3C(CC2)=CC(C#N)=CC3)CC1)(=O)C=4C5=C(N=CC4)C=CC=C5.Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (21.05 mM), Sonication is recommended.

DMSO: 40 mg/mL (84.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1051 mL	10.5257 mL	21.0513 mL	105.2565 mL
5 mM	0.4210 mL	2.1051 mL	4.2103 mL	21.0513 mL
10 mM	0.2105 mL	1.0526 mL	2.1051 mL	10.5257 mL
20 mM	0.1053 mL	0.5263 mL	1.0526 mL	5.2628 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0421 mL	0.2105 mL	0.4210 mL	2.1051 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc