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Clusterin Protein, Human, Recombinant (CLU34, His)

Catalog No. TMPY-01691
Synonyms: SGP-2, AAG4, KUB1, CLI, CLU2, TRPM2, APO-J, SP-40, CLU1, clusterin, APOJ, TRPM-2, NA1/NA2, SGP2

Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.

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Clusterin Protein, Human, Recombinant (CLU34, His)
Pack Size Availability Price/USD Quantity
50 μg In stock $ 228.00
100 μg 5 days $ 401.00
200 μg 5 days $ 700.00
500 μg 5 days $ 1,460.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Testing in progress
Description Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number P10909-2
Synonyms SGP-2, AAG4, KUB1, CLI, CLU2, TRPM2, APO-J, SP-40, CLU1, clusterin, APOJ, TRPM-2, NA1/NA2, SGP2
Construction The Human CLU isoform long (NP_001822.2) (Met 1-Glu 501) was expressed, with a C-terminal polyhistidine tag.
Protein Purity > 92 % as determined by SDS-PAGE

Molecular Weight 51.5 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

References and Literature

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Keywords

Clusterin Protein, Human, Recombinant (CLU34, His) TRPM 2 CLU 2 SGP-2 SGP 2 AAG-4 AAG4 KUB-1 KUB1 CLI CLU2 CLU-2 SP 40 KUB 1 TRPM2 APO-J AAG 4 SP-40 CLU1 SP40 CLU-1 clusterin CLU 1 APOJ TRPM-2 NA1/NA2 SGP2 recombinant recombinant-proteins proteins protein

 

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