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Acyclovir

Name: Acyclovir
Brand: TargetMol
SKU: T1454
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Acycloguanosine, Aciclovir) Copy Product Info

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Synonyms: Acycloguanosine, Aciclovir

Catalog No. T1454 Copy Product Info

Purity: 99.77%

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Acyclovir (Aciclovir) is a guanine analog and orally active antiviral agent characterized by a narrow antiviral spectrum, high selectivity, and low toxicity. Acyclovir exhibits activity against HSV-1 (IC50 = 0.85 μM), HSV-2 (IC50 = 0.86 μM), and varicella-zoster virus. Acyclovir can be used for herpesvirus treatment research.

Cas No. 59277-89-3

Pack Size	Price	USA Stock	Global Stock
25 mg	$39	In Stock	In Stock
50 mg	$51	In Stock	In Stock
100 mg	$80	In Stock	In Stock
200 mg	$104	In Stock	In Stock
500 mg	$131	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.77%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Acyclovir (Aciclovir) is a guanine analog and orally active antiviral agent characterized by a narrow antiviral spectrum, high selectivity, and low toxicity. Acyclovir exhibits activity against HSV-1 (IC50 = 0.85 μM), HSV-2 (IC50 = 0.86 μM), and varicella-zoster virus. Acyclovir can be used for herpesvirus treatment research.
Targets & IC50	HSV1:0.85 μM (IC50), HSV2:0.86 μM (IC50)
In vitro	Methods: Flow cytometry was used to analyze the cell cycle distribution of Jurkat cells treated with 10 and 100 μM acyclovir at 24, 48, and 72 hours. Results: Acyclovir induced S-phase arrest in Jurkat cells, and the sub-G1 apoptotic peak was significantly elevated at 72 hours. [4] Methods: Cell viability of Jurkat, U937, and K562 leukemia cells treated with 3–100 μM acyclovir for 24, 48, and 72 hours was assessed using the trypan blue staining Methods. Results: Acyclovir inhibited Jurkat cell viability in a dose- and time-dependent manner, while its inhibitory effect on U937 and K562 cells was weaker. [4]
In vivo	Methods: Female Danish Landrace pigs (n=6, weight 37–48 kg) received a single intravenous bolus injection of Acyclovir (10 mg/kg). Monitoring was conducted for 8 hours post-administration, with sampling every 30 minutes. Results: Plasma drug concentrations peaked rapidly, but CNS distribution was slow and limited. [1] Methods: Four healthy Asian elephant calves received a single intravenous bolus of Acyclovir (15 mg/kg). Blood samples were collected pre-dose and at 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 12, 24, 36, and 48 h post-administration. Plasma drug concentrations were measured by LC-MS/MS. Results: At 12 h post-administration, plasma concentrations remained above the IC50 for HSV-1/2 and EHV-1. [2] Methods: Male Sprague-Dawley rats received epidural Acyclovir (0.3 mg, 0.6 mg, 0.9 mg) (dissolved in 100 μL) or intravenous Acyclovir (3 mg, 6 mg, 9 mg) (dissolved in 2 mL saline). Blood and cerebrospinal fluid (CSF) samples were collected 1 hour post-administration. Results: CSF concentrations in the epidural group were significantly higher than those in the IV group (P<0.05), while plasma concentrations were significantly lower than those in the IV group (P<0.05).[3]
Synonyms	Acycloguanosine, Aciclovir
Kinase Assay	Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method.

Chemical Properties

Molecular Weight	225.2
Formula	C₈H₁₁N₅O₃
Cas No.	59277-89-3
Smiles	NC1=NC(=O)C2=C(N1)N(COCCO)C=N2
Relative Density.	1.77

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 42.92 mg/mL (190.59 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4405 mL	22.2025 mL	44.4050 mL	222.0249 mL
5 mM	0.8881 mL	4.4405 mL	8.8810 mL	44.4050 mL
10 mM	0.4440 mL	2.2202 mL	4.4405 mL	22.2025 mL
20 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1012 mL
50 mM	0.0888 mL	0.4440 mL	0.8881 mL	4.4405 mL
100 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2202 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.