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MIRA-1

Name: MIRA-1
Brand: TargetMol
SKU: T22980
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22980Cas No. 72835-26-8

Alias WRN Helicase Inhibitor, p53 Activator VIII, NSC 19630, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate

MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.

MIRA-1

🥰Excellent

Purity: 99.94%

Catalog No. T22980Alias WRN Helicase Inhibitor, p53 Activator VIII, NSC 19630, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionateCas No. 72835-26-8

MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$103	In Stock	In Stock
50 mg	$153	In Stock	In Stock
100 mg	$227	In Stock	In Stock
200 mg	$335	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.
Targets&IC50	WRN helicase:20 µM, p53:10μM
In vitro	MIRA-1 induces p53 transcriptional transactivation of p21, MDM2, and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro with an IC50 of 10μM[1].
Synonyms	WRN Helicase Inhibitor, p53 Activator VIII, NSC 19630, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate

Chemical Properties

Molecular Weight	183.16
Formula	C₈H₉NO₄
Cas No.	72835-26-8
Smiles	CCC(=O)OCN1C(=O)C=CC1=O
Relative Density.	1.307g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (109.19 mM), Sonication is recommended.

Ethanol: 20 mg/mL (109.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	5.4597 mL	27.2985 mL	54.5971 mL	272.9854 mL
5 mM	1.0919 mL	5.4597 mL	10.9194 mL	54.5971 mL
10 mM	0.5460 mL	2.7299 mL	5.4597 mL	27.2985 mL
20 mM	0.2730 mL	1.3649 mL	2.7299 mL	13.6493 mL
50 mM	0.1092 mL	0.5460 mL	1.0919 mL	5.4597 mL
100 mM	0.0546 mL	0.2730 mL	0.5460 mL	2.7299 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc