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Estrogen receptor modulator 1

Name: Estrogen receptor modulator 1
Brand: TargetMol
SKU: T15249
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15249Cas No. 63676-22-2

Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).

Estrogen receptor modulator 1

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Purity: 98.00%

Catalog No. T15249Cas No. 63676-22-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$58	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.00%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).
In vitro	Estrogen receptor modulator 1 (100 nM; 9 days) obviously inhibits the growth of MCF-7:5C cell. It also causes apoptosis in these cells 6 days. Estrogen receptor modulator 1 (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation [2].
In vivo	Estrogen receptor modulator 1 (1.5 mg/animal; p.o.; daily for 2 weeks) induces regression of T47D:A18/PKCα tumors [2].

Chemical Properties

Molecular Weight	242.29
Formula	C₁₄H₁₀O₂S
Cas No.	63676-22-2
Smiles	Oc1ccc(cc1)-c1cc2ccc(O)cc2s1
Relative Density.	1.383

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (206.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1273 mL	20.6364 mL	41.2729 mL	206.3643 mL
5 mM	0.8255 mL	4.1273 mL	8.2546 mL	41.2729 mL
10 mM	0.4127 mL	2.0636 mL	4.1273 mL	20.6364 mL
20 mM	0.2064 mL	1.0318 mL	2.0636 mL	10.3182 mL
50 mM	0.0825 mL	0.4127 mL	0.8255 mL	4.1273 mL
100 mM	0.0413 mL	0.2064 mL	0.4127 mL	2.0636 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc