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Estrogen receptor modulator 1

🥰Excellent
Catalog No. T15249Cas No. 63676-22-2

Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).

Estrogen receptor modulator 1

Estrogen receptor modulator 1

🥰Excellent
Purity: 98.00%
Catalog No. T15249Cas No. 63676-22-2
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$30In StockIn Stock
25 mg$58In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]
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Purity:98.00%
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Product Introduction

Bioactivity
Description
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).
In vitro
Estrogen receptor modulator 1 (100 nM; 9 days) obviously inhibits the growth of MCF-7:5C cell. It also causes apoptosis in these cells 6 days. Estrogen receptor modulator 1 (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation [2].
In vivo
Estrogen receptor modulator 1 (1.5 mg/animal; p.o.; daily for 2 weeks) induces regression of T47D:A18/PKCα tumors [2].
Chemical Properties
Molecular Weight242.29
FormulaC14H10O2S
Cas No.63676-22-2
SmilesOc1ccc(cc1)-c1cc2ccc(O)cc2s1
Relative Density.1.383
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (206.36 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1273 mL20.6364 mL41.2729 mL206.3643 mL
5 mM0.8255 mL4.1273 mL8.2546 mL41.2729 mL
10 mM0.4127 mL2.0636 mL4.1273 mL20.6364 mL
20 mM0.2064 mL1.0318 mL2.0636 mL10.3182 mL
50 mM0.0825 mL0.4127 mL0.8255 mL4.1273 mL
100 mM0.0413 mL0.2064 mL0.4127 mL2.0636 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

tumorselectivemiceMCF-7:5CInhibitorinhibitEstrogenReceptorEstrogen Receptor/ERREstrogen receptor modulator-1Estrogen receptor modulator1Estrogen receptor modulator 1Estrogen ReceptorERRcellscancerbreastathymic
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