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Pratensein

Name: Pratensein
Brand: TargetMol
SKU: TN2100
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2100Cas No. 2284-31-3

Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.

Pratensein

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Purity: 99.90%

Catalog No. TN2100Cas No. 2284-31-3

Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.

Pack Size	Price	Availability
1 mg	$158	In Stock
5 mg	$396	In Stock
10 mg	$562	In Stock
25 mg	$889	In Stock
50 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$396	In Stock

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Purity:99.90%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.

In vitro

Protective effect of five isoflavones (formononetin, daidzein, Pratensein, calycosin and irilone) from Trifolium pratense on lipopolysaccharide-induced dopaminergic neurodegeneration was studied for the first time. The results showed that all five isoflavones attenuated LPS-induced decrease in dopamine uptake and the number of dopaminergic neurons in a dose-dependent manner in rat mesencephalic neuron-glia cultures. Moreover, they also significantly inhibited LPS-induced activation of microglia and production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. In addition, the rank order of protective potency of five isoflavones was: Pratensein>daidzein>calycosin>formononetin>irilone.

Chemical Properties

Molecular Weight	300.26
Formula	C₁₆H₁₂O₆
Cas No.	2284-31-3
Smiles	COc1ccc(cc1O)-c1coc2cc(O)cc(O)c2c1=O
Relative Density.	1.512g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (166.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3304 mL	16.6522 mL	33.3045 mL	166.5223 mL
5 mM	0.6661 mL	3.3304 mL	6.6609 mL	33.3045 mL
10 mM	0.3330 mL	1.6652 mL	3.3304 mL	16.6522 mL
20 mM	0.1665 mL	0.8326 mL	1.6652 mL	8.3261 mL
50 mM	0.0666 mL	0.3330 mL	0.6661 mL	3.3304 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6652 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc