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GABAA receptor agent 1

Name: GABAA receptor agent 1
Brand: TargetMol
SKU: T11349
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11349Cas No. 1571-87-5

GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.

GABAA receptor agent 1

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Purity: 99.31%

Catalog No. T11349Cas No. 1571-87-5

GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$238	In Stock	In Stock
50 mg	$358	In Stock	In Stock
100 mg	$521	In Stock	In Stock
200 mg	$718	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.31%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

GABAA receptor agent 1 AI Summary

GABAA receptor agent 1 exhibits a diverse spectrum of bioactivities. Notable activities include modulation of miRNAs and activation of miR-21 with a potency of 369.0 nM, modulation of Lamin A splicing with a potency of 22387.2 nM, inhibition of Tau fibril formation at 39810.7 nM, activation of the Rab9 promoter with a potency of 1584.9 nM, enhancement of SMN2 splice variant expression at 3162.3 nM, and inhibition of Aldehyde Dehydrogenase 1 (ALDH1A1) at 19952.6 nM. Additionally, it modulates lipid storage in Drosophila S3 cells with a potency of 32642.7 nM and inhibits Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 354.8 nM. The compound also demonstrates inhibitory effects on various tumor cell lines, including breast, renal, lung, melanoma, ovarian, leukemia, and colon cells, with GI50 values ranging from 14,652.54 nM to 33,036.95 nM. GABAA receptor agent 1 inhibits Bothrops atrox venom phosphodiesterase-1 with an IC50 of 120000.0 nM, as determined by spectrophotometric analysis. Furthermore, it shows antileishmanial activity against the promastigote form of Leishmania major with an IC50 value of 0.64 µg/mL after 72 hours of treatment. Lastly, GABAA receptor agent 1 functions as an antagonist at the human NPBWR1 receptor, inhibiting agonist-induced cAMP accumulation with an IC50 of 2687.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.

Chemical Properties

Molecular Weight	273.67
Formula	C₁₃H₈ClN₃O₂
Cas No.	1571-87-5
Smiles	[O-][N+](=O)C1=CC=C2N=C(NC2=C1)C1=CC=C(Cl)C=C1
Relative Density.	1.485 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (91.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6540 mL	18.2702 mL	36.5404 mL	182.7018 mL
5 mM	0.7308 mL	3.6540 mL	7.3081 mL	36.5404 mL
10 mM	0.3654 mL	1.8270 mL	3.6540 mL	18.2702 mL
20 mM	0.1827 mL	0.9135 mL	1.8270 mL	9.1351 mL
50 mM	0.0731 mL	0.3654 mL	0.7308 mL	3.6540 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc