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HER2/ERBB2 Protein, Human, Recombinant , Biotinylated

Catalog No. TMPY-05239
Synonyms: CD340, ENVW, ENV, HER2, HERV7Q, HERVWENV, HERV-7q, HER-2, TKR1, EGFR2, HERVW, NGL, NEU, erb-b2 receptor tyrosine kinase 2, MLN 19, HER-2/neu, HERV-W-ENV, ERVWE1, MLN19

HER2/ERBB2 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.

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HER2/ERBB2 Protein, Human, Recombinant , Biotinylated
Pack Size Availability Price/USD Quantity
20 μg In stock $ 197.00
100 μg 5 days $ 468.00
200 μg 5 days $ 797.00
500 μg 5 days $ 1,610.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information 1. Immobilized Her2/ERBB2 Protein, Human, Recombinant (ECD), Biotinylated at 2 μg/ml (100 μl/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 10-50 ng/mL. 2. Using the Octet RED System, the affinity constant (Kd) of Her2 / ERBB2 Protein, Human, Recombinant, Biotinylated bound to Pertuzumab was 0.1 nM.

Description HER2/ERBB2 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
Species Human
Expression System HEK293 Cells
Tag Tag Free
Accession Number P04626-1
Synonyms CD340, ENVW, ENV, HER2, HERV7Q, HERVWENV, HERV-7q, HER-2, TKR1, EGFR2, HERVW, NGL, NEU, erb-b2 receptor tyrosine kinase 2, MLN 19, HER-2/neu, HERV-W-ENV, ERVWE1, MLN19
Construction The Human ERBB2 (NP_004439.2) (Met1-Thr652) was expressed with five amino acids (DDDDK) at the C-terminus. The purified protein was biotinylated in vitro.
Protein Purity > 95 % as determined by SDS-PAGE.

Molecular Weight 70 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

References and Literature

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Keywords

HER2/ERBB2 Protein, Human, Recombinant , Biotinylated CD340 ENVW CD-340 MLN-19 ENV HER 2 HER2 HERV7Q HERVWENV HERV-7q CD 340 ERVWE 1 HER-2 TKR-1 TKR1 EGFR2 TKR 1 HERVW NGL NEU erb-b2 receptor tyrosine kinase 2 MLN 19 HER-2/neu HERV-W-ENV ERVWE-1 ERVWE1 MLN19 recombinant recombinant-proteins proteins protein

 

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