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D-(+)-Glucono-1,5-lactone

Name: D-(+)-Glucono-1,5-lactone
Brand: TargetMol
SKU: T0933
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0933Cas No. 90-80-2

Alias Gluconolactone, Gluconic acid lactone, Delta-Gluconolactone

D-(+)-Glucono-1,5-lactone (Gluconolactone) is a naturally occurring food additive used as a sequestrant, acidifier, curing agent, pickling agent, or leavening agent. It is a cyclic ester of D-gluconic acid and appears as a white, odorless crystalline powder.

D-(+)-Glucono-1,5-lactone

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Purity: 99.64%

Catalog No. T0933Alias Gluconolactone, Gluconic acid lactone, Delta-GluconolactoneCas No. 90-80-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 g	$38	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.64%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

D-(+)-Glucono-1,5-lactone AI Summary

D-(+)-Glucono-1,5-lactone inhibits beta-glucosidase activity with a Ki value of 30000.0 nM. It shows bioactivity in assays related to modulating Lamin A splicing with a potency of 794.3 nM and blocking the entry of the Ebola virus with AC50 values of 1258.9 nM and 1.259 μM. The compound also inhibits sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells at 10 μM, with inhibition percentages of 81.83% and 89.12% respectively. Additionally, D-(+)-Glucono-1,5-lactone exhibits antiviral activity against SARS-CoV-2 by inhibiting the cytotoxicity of VERO-6 cells, although it shows an IC50 value higher than 20,000 nM, indicating relatively low potency in this assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-(+)-Glucono-1,5-lactone (Gluconolactone) is a naturally occurring food additive used as a sequestrant, acidifier, curing agent, pickling agent, or leavening agent. It is a cyclic ester of D-gluconic acid and appears as a white, odorless crystalline powder.
Synonyms	Gluconolactone, Gluconic acid lactone, Delta-Gluconolactone

Chemical Properties

Molecular Weight	178.14
Formula	C₆H₁₀O₆
Cas No.	90-80-2
Smiles	C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(=O)O1
Relative Density.	1.72 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (280.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6136 mL	28.0678 mL	56.1356 mL	280.6781 mL
5 mM	1.1227 mL	5.6136 mL	11.2271 mL	56.1356 mL
10 mM	0.5614 mL	2.8068 mL	5.6136 mL	28.0678 mL
20 mM	0.2807 mL	1.4034 mL	2.8068 mL	14.0339 mL
50 mM	0.1123 mL	0.5614 mL	1.1227 mL	5.6136 mL
100 mM	0.0561 mL	0.2807 mL	0.5614 mL	2.8068 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc