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BMS-641988

Name: BMS-641988
Brand: TargetMol
SKU: T67818
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67818 Copy Product Info

Purity: 99.92%

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BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.

Cas No. 1093276-09-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$163	In Stock	In Stock
5 mg	$400	In Stock	In Stock
10 mg	$600	In Stock	In Stock
25 mg	$959	In Stock	In Stock
50 mg	$1,280	In Stock	In Stock
100 mg	$1,750	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.92%

Appearance:Solid

Color:White to Yellow

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.
In vivo	Sixty-one men with CRPC were treated with daily BMS-641988 (5 to 150 mg). Seventeen of 23 evaluable patients (74%) exhibited stable disease on imaging (median 15 weeks; range 8-32), and 10 of 61 patients (16%) achieved a ≥ 30% decline in levels of prostate-specific antigen (PSA).[1]

Chemical Properties

Molecular Weight	471.45
Formula	C₂₀H₂₀F₃N₃O₅S
Cas No.	1093276-09-5
Smiles	C[C@@]12[C@@]3([C@]([C@@](C)(O1)[C@H](NS(CC)(=O)=O)C2)(C(=O)N(C3=O)C4=CC(C(F)(F)F)=C(C#N)C=C4)[H])[H]
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (106.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 5 mg/mL (10.61 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.61 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1211 mL	10.6056 mL	21.2112 mL	106.0558 mL
5 mM	0.4242 mL	2.1211 mL	4.2422 mL	21.2112 mL
10 mM	0.2121 mL	1.0606 mL	2.1211 mL	10.6056 mL
20 mM	0.1061 mL	0.5303 mL	1.0606 mL	5.3028 mL
50 mM	0.0424 mL	0.2121 mL	0.4242 mL	2.1211 mL
100 mM	0.0212 mL	0.1061 mL	0.2121 mL	1.0606 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc